seven days ish
#semaglutide 2025-12-19
Friday62 messages13 participantstimes are UTC
Highlights from this day
- taper_tess — vial units and pen clicks are different systems, mixing the two is how people end up wrong 21:16
- taper_tess — i held at 1.7 for 8 months and it was the best decision i made 21:17
- tenpence — did anyone titrate slower than four weeks a step and how did that go 22:23
- alcohol_hits — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 22:53
how many weeks before you noticed anything at 0.5
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
five week steps worked better for me than four, purely on how the second week felt
compounded and brand felt the same to me at 2.5, which is one person and nothing more, i could be wrong
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five week steps worked better for me than four, purely on how the second week felt
the plateau hit me at 13 weeks and moved again about a month later without a dose change
STEP 1 ran to 68 weeks. thats the one everyone half remembers
thats STEP 1
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
coming back to this steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
steady state takes weeks
went too fast once
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what did SELECT actually measure, i see it quoted for everything
quick one went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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is there a reason to hold at 1.7 rather than going to 2.4
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not the same trial
my 40 vial in 2ml gives 5mg/ml so 10 lands on 12 units, thats why i picked that volume
follow up im at 15 and stuck, did anyone break a plateau without going up
does the seven day half life mean the last two days are weaker
does anyone actually run a five week step instead of four
plateaus move
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is the plateau at 13 weeks normal or am i doing something wrong
anyone compared their 2 vial dosing against the pen increments
anyone gone from 2.4 straight to 1 or is that too big a jump
how did people handle the jump from 1 to 1.7
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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i held at 1.7 for 8 months and it was the best decision i made
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same dose day
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it
follow up whats the actual licensed ceiling, i keep seeing different numbers
sorry to jump in went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
did the STEP 4 withdrawal arm show what i think it showed
5 months at 2.4 and the honest summary is diminishing returns after the first half, thats just me
On this day 7 years ago this channel logged 68 messages.
vials not pens here
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moving my dose day by a day or two never did anything noticeable for me, i could be wrong
SELECT wasnt weight
did anybody find a difference between KP and pharmacy at the same 1
give it four weeks
genuine question does the licensed ceiling for weight differ from the diabetes one
€120 a month for compounded against what brand costs locally is why most people here use vials
my PeptideMeter report on the QSC vial came back 98.1 against a certificate saying 98.6
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
did anyone titrate slower than four weeks a step and how did that go
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
was SELECT the one that ran to 68 weeks or am i mixing them up
the long half life flattens the trough more than people expect, i never felt a day seven dip
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
quick one lost about 44kg on the low doses before i even got to 1, which surprised me
for the archive STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
2.4 is the ceiling, ymmv
is 2.4 the top or do people go past it
i dont think the plateau is a dose problem most of the time, but i cant prove that
how long till steady state, ive read the half life is about a week
did anyone hold at 0.5 longer than four weeks before going up
dose day is sunday for me only because thats when i remember, not because sunday matters
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the appetite effect faded for me around 20 months and going up fixed it for a while, for what its worth
how long did the first 39kg take for people at the low doses
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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