STEP is several trials, so saying STEP said x is usually wrong without a number after it
❤️5✅18
#semaglutide 2026-01-04
Sunday72 messages14 participantstimes are UTC
Highlights from this day
- gradient_greg — STEP is several trials, so saying STEP said x is usually wrong without a number after it 12:52
- gradient_greg — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 13:24
- factory_direct_fi — restarted after 11 months off at a low dose and the nausea arrived exactly like the first time 14:00
- cagri_curious — i dont think the plateau is a dose problem most of the time, but i cant prove that 16:37
im at 1.7 and stuck, did anyone break a plateau without going up
2.4 is the ceiling
janoshik-kp-0925.pdf
2 pages · 842 KB · not retained in the public archive
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
mine faded too
⚠️2
held there too
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
❤️13🙏18
follow up 21 months at 2.4 and the honest summary is diminishing returns after the first half
slower worked better
€120 a month for compounded against what brand costs locally is why most people here use vials
thats STEP 1
how long till steady state, ive read the half life is about a week
restarted after 11 months off at a low dose and the nausea arrived exactly like the first time
❤️4🧊17
plateaus move
follow up steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the appetite effect faded for me around 4 months and going up fixed it for a while
chromatogram-overlay.png
1240 × 720 · 177 KB · not retained in the public archive
did anyone titrate slower than four weeks a step and how did that go
ok so STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
🙏1🔥6
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
compounded and brand felt the same to me at 1, which is one person and nothing more
held at 0.25 and lost 28lb over 9 months, slower than the trials and fine by me
vials not pens here
[redacted at member request] · archive policy
🧪9🎉14
Purity check: no report on file for lot B-0329. Nothing logged either way.
lost about 44kg on the low doses before i even got to 1, which surprised me
[edited]dose day is sunday for me only because thats when i remember, not because sunday matters
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
STEP 1 ran to 68 weeks. thats the one everyone half remembers
genuine question whats the actual licensed ceiling, i keep seeing different numbers
does the licensed ceiling for weight differ from the diabetes one
the long half life flattens the trough more than people expect, i never felt a day seven dip, ask me again in a month
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, thats one data point
sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
did anyone hold at 2.5 longer than four weeks before going up
16:22ferrous_ash pinned a message to this channel
my 2 vial in 2.5ml gives 2.5mg/ml so 1.7 lands on 40 units, thats why i picked that volume
💀1👍1🎉1
my PeptideMeter report on the GL Biochem vial came back 99.4 against a certificate saying 98.6
i dont think the plateau is a dose problem most of the time, but i cant prove that
😂16
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, ymmv
❤️6😂1
how long did the first 11kg take for people at the low doses
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
Assay note: ERP lot C-4402 reported at 99.4% of label content.
i held at 2 for 6 months and it was the best decision i made
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
🔥3😂11✅1
moving my dose day by a day or two never did anything noticeable for me
💀1🙏1
slightly off topic but give it four weeks
unrelated but is there a reason to hold at 1.7 rather than going to 2.4
not the same trial
same dose day
the plateau hit me at 13 weeks and moved again about a month later without a dose change
is 2.4 the top or do people go past it
SELECT wasnt weight
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
vial units and pen clicks are different systems, mixing the two is how people end up wrong
compounded and brand felt the same to me at 2, which is one person and nothing more
seven days ish
steady state takes weeks
😂1📉1💀17
quick one what did SELECT actually measure, i see it quoted for everything
thats STEP 1
👍6🧪1
20 months at 2.4 and the honest summary is diminishing returns after the first half
went too fast once
2.4 is the ceiling
i held at 5 for 4 months and it was the best decision i made
how did people handle the jump from 1 to 1.7
went too fast once
give it four weeks, happy to be corrected
📉4👍3
mine faded too
update on the earlier thing plateaus move
half life is about a week so youre roughly four to five weeks to steady state on any new dose
vials not pens here
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
anyone gone from 10 straight to 12 or is that too big a jump
plateaus move
🧊3😂4
is the plateau at 12 weeks normal or am i doing something wrong