#semaglutide 2026-01-13

STEP 1 ran to 68 weeks. thats the one everyone half remembers

half life is about a week so youre roughly four to five weeks to steady state on any new dose

New independent result logged — QST, lot C-4402, purity 99.2% (PeptideMeter).

mine faded too

my VendorInvestigate report on the JEEP vial came back 99.2 against a certificate saying 99.4, ill dig out the number

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

genuine question was SURPASS-2 the one that ran to 68 weeks or am i mixing them up

the plateau hit me at 23 weeks and moved again about a month later without a dose change

update on the earlier thing i dont think the plateau is a dose problem most of the time, but i cant prove that

anyone gone from 0.5 straight to 12 or is that too big a jump

€38 a month for compounded against what brand costs locally is why most people here use vials

dose day is sunday for me only because thats when i remember, not because sunday matters, i have it written down somewhere

the appetite effect faded for me around 1 months and going up fixed it for a while

compounded and brand felt the same to me at 2.5, which is one person and nothing more

is there a reason to hold at 1.7 rather than going to 2.4

five week steps worked better for me than four, purely on how the second week felt, thats one data point

update on the earlier thing SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

update on the earlier thing anyone compared their 2 vial dosing against the pen increments

did anyone hold at 5 longer than four weeks before going up

steady state takes weeks

the long half life flattens the trough more than people expect, i never felt a day seven dip

vials not pens here

held there too

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, for what its worth