changed my mind on the four week rule, i think it depends entirely on how the current dose feels
#semaglutide 2026-01-17
Saturday58 messages13 participantstimes are UTC
Highlights from this day
- VialBot — Verification log updated: MKM — evidence added, status unchanged. 17:11
- new_here_nat — STEP is several trials, so saying STEP said x is usually wrong without a number after it 20:00
- reta_low_dose — half life is about a week so youre roughly four to five weeks to steady state on any new dose 20:39
- reta_low_dose — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 21:34
brand vs compounded, is there a difference people can actually feel
steady state takes weeks
vial units and pen clicks are different systems, mixing the two is how people end up wrong
right so does moving my dose day by two days matter with a seven day half life
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, take that with a pinch of salt
seven days ish
did anyone hold at 5 longer than four weeks before going up
€240 a month for compounded against what brand costs locally is why most people here use vials
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
give it four weeks
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not the same trial
Verification log updated: MKM — evidence added, status unchanged.
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my VendorInvestigate report on the Homopeptide vial came back 96.8 against a certificate saying 99
i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it
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how many weeks before you noticed anything at 5
is there a reason to hold at 1.7 rather than going to 2.4
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
lost about 47kg on the low doses before i even got to 1, which surprised me
held there too
the appetite effect faded for me around 20 months and going up fixed it for a while
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is the plateau usually appetite coming back or just the scale stopping
same dose day
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, thats just me
how did people handle the jump from 1 to 1.7
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the plateau hit me at 8 weeks and moved again about a month later without a dose change, someone check my working
plateaus move
whats the actual licensed ceiling, i keep seeing different numbers
vials not pens here
while im here the long half life flattens the trough more than people expect, i never felt a day seven dip
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anyone gone from 15 straight to 10 or is that too big a jump
is the plateau at 5 weeks normal or am i doing something wrong
slower worked better
went too fast once
im at 0.25 and stuck, did anyone break a plateau without going up
2.4 is the ceiling
SELECT wasnt weight
[edited]lot-log.csv
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back after 25 months off, do i restart at 0.25 or somewhere higher
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was STEP 1 the one that ran to 68 weeks or am i mixing them up
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does anyone actually run a five week step instead of four
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
i dont think the plateau is a dose problem most of the time, but i cant prove that
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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thats STEP 1
slightly off topic but how long till steady state, ive read the half life is about a week
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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compounded and brand felt the same to me at 15, which is one person and nothing more, happy to be corrected
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genuine question if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
dose day is sunday for me only because thats when i remember, not because sunday matters
anyone compared their 2.5 vial dosing against the pen increments
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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five week steps worked better for me than four, purely on how the second week felt
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how long did the first 8kg take for people at the low doses
my 2 vial in 5ml gives 2.5mg/ml so 1 lands on 5 units, thats why i picked that volume
STEP is several trials, so saying STEP said x is usually wrong without a number after it