vialroom

#semaglutide 2026-01-22

Thursday34 messages7 participantstimes are UTC
Highlights from this day
  • acetate_ash — for the archive held at 10 and lost 60lb over 24 months, slower than the trials and fine by me 21:48
  • nordic_price_nils — does the seven day half life mean the last two days are weaker 22:37
  • VialBot — Testing queue: 9 submissions open, 68 awaiting dispatch. 23:12
AA

for the archive held at 10 and lost 60lb over 24 months, slower than the trials and fine by me

Cited study
Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)
JAMA · 2022
Weekly against daily, head to head.

lost about 20kg on the low doses before i even got to 1, which surprised me

🧊6

slower worked better

AA

was STEP 1 the one that ran to 68 weeks or am i mixing them up

did anyone hold at 0.25 longer than four weeks before going up

CO

STEP is several trials, so saying STEP said x is usually wrong without a number after it

right so moving my dose day by a day or two never did anything noticeable for me, i have it written down somewhere

not the same trial

2.4 is the ceiling

😂4🧊3

is the plateau at 19 weeks normal or am i doing something wrong
14 months at 2.4 and the honest summary is diminishing returns after the first half

SELECT wasnt weight

NP

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, we shall see

mine faded too

plateaus move

does moving my dose day by two days matter with a seven day half life

*Janoshik not the other one

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

sorry to jump in back after 22 months off, do i restart at 0.25 or somewhere higher

VB

Testing queue: 9 submissions open, 68 awaiting dispatch.

📉1
SN

for the archive 26 months at 2.4 and the honest summary is diminishing returns after the first half