anyone compared their 10 vial dosing against the pen increments
#semaglutide 2026-02-13
Friday67 messages10 participantstimes are UTC
Highlights from this day
- amber_vial — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, ymmv 20:22
- acer_asks — anyone gone from 2.4 straight to 0.5 or is that too big a jump 20:39
- tb500_tobias — did anybody find a difference between SSA and pharmacy at the same 10 20:58
- acer_asks — STEP 1 ran to 68 weeks. thats the one everyone half remembers 21:00
- cat_on_the_tray — moving my dose day by a day or two never did anything noticeable for me 21:59
STEP is several trials, so saying STEP said x is usually wrong without a number after it
plateaus move
is 2.4 the top or do people go past it
SELECT wasnt weight
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how long did the first 41kg take for people at the low doses
right so what did SELECT actually measure, i see it quoted for everything
give it four weeks
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slower worked better
the appetite effect faded for me around 10 months and going up fixed it for a while
for the archive did anyone titrate slower than four weeks a step and how did that go
whats the actual licensed ceiling, i keep seeing different numbers
held there too
my dose day drifted from friday to sunday, does that reset anything
does moving my dose day by two days matter with a seven day half life
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, not advice obviously
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
did the STEP 4 withdrawal arm show what i think it showed
went too fast once
2.4 is the ceiling
how did people handle the jump from 1 to 1.7
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgim at 1.7 and stuck, did anyone break a plateau without going up
mine faded too
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
half life is about a week so youre roughly four to five weeks to steady state on any new dose, from memory
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
did anyone hold at 2.4 longer than four weeks before going up
[redacted at member request] · archive policy
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, ymmv
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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back after 22 months off, do i restart at 0.25 or somewhere higher
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
i stayed on 1.7 for 12 months and never went to 2.4, appetite was already where i needed it
anyone gone from 2.4 straight to 0.5 or is that too big a jump
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does anyone actually run a five week step instead of four
same dose day
is the plateau usually appetite coming back or just the scale stopping
does the seven day half life mean the last two days are weaker
lost about 29kg on the low doses before i even got to 1, which surprised me, n of 1 obviously
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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did anybody find a difference between SSA and pharmacy at the same 10
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 1 ran to 68 weeks. thats the one everyone half remembers
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does the licensed ceiling for weight differ from the diabetes one
18 months at 2.4 and the honest summary is diminishing returns after the first half
seven days ish
follow up went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
the plateau hit me at 8 weeks and moved again about a month later without a dose change, not advice obviously
i dont think the plateau is a dose problem most of the time, but i cant prove that
was STEP 1 the one that ran to 68 weeks or am i mixing them up
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
how many weeks before you noticed anything at 5
not the same trial
compounded and brand felt the same to me at 5, which is one person and nothing more, i could be wrong
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vials not pens here
seven days ish
give it four weeks
moving my dose day by a day or two never did anything noticeable for me
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restarted after 14 months off at a low dose and the nausea arrived exactly like the first time, anyway
the long half life flattens the trough more than people expect, i never felt a day seven dip
*Janoshik not the other one
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
im 6 months in at 2.4 and the appetite effect faded, is that a thing
steady state takes weeks
my 30 vial in 2.5ml gives 10mg/ml so 5 lands on 8 units, thats why i picked that volume
my Medutest report on the FGP vial came back 96.8 against a certificate saying 98.1, happy to be corrected
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, ask me again in a month
half life is about a week so youre roughly four to five weeks to steady state on any new dose
genuine question is the plateau at 31 weeks normal or am i doing something wrong