my dose day drifted from friday to sunday, does that reset anything
#semaglutide 2026-02-19
Thursday50 messages12 participantstimes are UTC
Highlights from this day
- birch_bloods — did anyone hold at 2.4 longer than four weeks before going up 18:48
- hydrate_hana — dose day is sunday for me only because thats when i remember, not because sunday matters 19:03
- tarpit_tam — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 20:55
compounded and brand felt the same to me at 2, which is one person and nothing more
did anyone titrate slower than four weeks a step and how did that go
how long till steady state, ive read the half life is about a week
19 months at 2.4 and the honest summary is diminishing returns after the first half
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
whats the actual licensed ceiling, i keep seeing different numbers
same dose day
im 7 months in at 1.7 and the appetite effect faded, is that a thing
slower worked better
five week steps worked better for me than four, purely on how the second week felt
ok so vial units and pen clicks are different systems, mixing the two is how people end up wrong, your mileage will differ
is there a reason to hold at 1.7 rather than going to 2.4
what did SELECT actually measure, i see it quoted for everything
anyone compared their 8 vial dosing against the pen increments
the long half life flattens the trough more than people expect, i never felt a day seven dip, ymmv
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
does moving my dose day by two days matter with a seven day half life
while im here STEP is several trials, so saying STEP said x is usually wrong without a number after it, happy to be corrected
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did anyone hold at 2.4 longer than four weeks before going up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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SELECT wasnt weight
dose day is sunday for me only because thats when i remember, not because sunday matters
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgok so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
steady state takes weeks
coming back to this anyone gone from 0.25 straight to 7.5 or is that too big a jump
did the STEP 4 withdrawal arm show what i think it showed
thats STEP 1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how many weeks before you noticed anything at 1.7
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for the archive moving my dose day by a day or two never did anything noticeable for me
does anyone actually run a five week step instead of four
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
is the plateau usually appetite coming back or just the scale stopping
Batch lookup B-0114: 8 independent reports on file, earliest 2025-10-16.
slightly off topic but STEP 1 ran to 68 weeks. thats the one everyone half remembers
vials not pens here
does the licensed ceiling for weight differ from the diabetes one
not the same trial
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
is the plateau at 33 weeks normal or am i doing something wrong
2.4 is the ceiling
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
give it four weeks
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right so was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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my 20 vial in 3ml gives 5mg/ml so 2 lands on 40 units, thats why i picked that volume
Assay note: QST lot KP-0925 reported at 99.2% of label content.
did anybody find a difference between TFC and pharmacy at the same 10
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
seven days ish