quick one STEP 1 ran to 68 weeks. thats the one everyone half remembers
#semaglutide 2026-03-15
Sunday60 messages11 participantstimes are UTC
Highlights from this day
- VialBot — Archive lookup: cold_chain_cmdr first appears in this channel on 2025-09-22. 21:23
- private_script_pri — i dont think the plateau is a dose problem most of the time, but i cant prove that 21:46
- LC_MS_Lena — does anyone actually run a five week step instead of four 22:06
- private_script_pri — follow up i held at 2 for 3 months and it was the best decision i made 23:14
thats STEP 1
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
SELECT wasnt weight
how many weeks before you noticed anything at 5
*week 18 not week 8
held at 2 and lost 54lb over 23 months, slower than the trials and fine by me
Archive lookup: cold_chain_cmdr first appears in this channel on 2025-09-22.
❤️1🧊12
brand vs compounded, is there a difference people can actually feel
did anyone titrate slower than four weeks a step and how did that go
❤️2
is 2.4 the top or do people go past it
moving my dose day by a day or two never did anything noticeable for me
$240 a month for compounded against what brand costs locally is why most people here use vials
sorry to jump in restarted after 21 months off at a low dose and the nausea arrived exactly like the first time
for the archive the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
lost about 23kg on the low doses before i even got to 1, which surprised me
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
😂4⚠️2
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
✅7😂2
i dont think the plateau is a dose problem most of the time, but i cant prove that
🧪7💀10😂2
plateaus move
my 20 vial in 1ml gives 10mg/ml so 2.5 lands on 10 units, thats why i picked that volume
📉1
what did SELECT actually measure, i see it quoted for everything
vial units and pen clicks are different systems, mixing the two is how people end up wrong, take that with a pinch of salt
slower worked better
is the plateau usually appetite coming back or just the scale stopping
📈4
quick one SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
does anyone actually run a five week step instead of four
✅1👀15🧪11
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
is the plateau at 28 weeks normal or am i doing something wrong
vials not pens here
went too fast once
Assay note: SGN lot SG-1177 reported at 97.4% of label content.
mine faded too
im at 2.4 and stuck, did anyone break a plateau without going up
💀8🔥1🎉3
slightly off topic but did the STEP 4 withdrawal arm show what i think it showed
dose day is sunday for me only because thats when i remember, not because sunday matters
whats the actual licensed ceiling, i keep seeing different numbers
📈5
held there too
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
five week steps worked better for me than four, purely on how the second week felt
half life is about a week so youre roughly four to five weeks to steady state on any new dose
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
🤝2🎉1
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
anyone gone from 7.5 straight to 10 or is that too big a jump
[edited]going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
seven days ish
does the licensed ceiling for weight differ from the diabetes one
not the same trial
the plateau hit me at 14 weeks and moved again about a month later without a dose change
my PeptideMeter report on the QSC vial came back 99 against a certificate saying 99.2
anyone compared their 2.5 vial dosing against the pen increments
i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it
16 months at 2.4 and the honest summary is diminishing returns after the first half
how long did the first 43kg take for people at the low doses
follow up i held at 2 for 3 months and it was the best decision i made
👍2⚠️18
sorry to jump in licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, for what its worth
give it four weeks
🧪3🧊1
dose day is sunday for me only because thats when i remember, not because sunday matters
same dose day
SELECT wasnt weight
STEP is several trials, so saying STEP said x is usually wrong without a number after it