did anyone titrate slower than four weeks a step and how did that go
#semaglutide 2026-03-24
Tuesday54 messages12 participantstimes are UTC
Highlights from this day
- two_ml_two — quick one is 2.4 the top or do people go past it 20:59
- identity_shift — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 21:21
- tga_notice — does moving my dose day by two days matter with a seven day half life my Medutest report on the QSC vial came back 99.4 against a certificate saying 98.1 21:40
- zed_zeroes_in — how did people handle the jump from 1 to 1.7 22:11
- tga_notice — £55 a month for compounded against what brand costs locally is why most people here use vials 23:16
same dose day
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, ill dig out the number
anyone compared their 8 vial dosing against the pen increments
is the plateau usually appetite coming back or just the scale stopping
does the seven day half life mean the last two days are weaker
ok so changed my mind on the four week rule, i think it depends entirely on how the current dose feels
ok so my dose day drifted from friday to sunday, does that reset anything
right so half life is about a week so youre roughly four to five weeks to steady state on any new dose
vials not pens here
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
compounded and brand felt the same to me at 0.25, which is one person and nothing more
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held at 0.5 and lost 74lb over 11 months, slower than the trials and fine by me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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im 3 months in at 2.5 and the appetite effect faded, is that a thing
brand vs compounded, is there a difference people can actually feel
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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2.4 is the ceiling
seven days ish
quick one is 2.4 the top or do people go past it
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
five week steps worked better for me than four, purely on how the second week felt
how many weeks before you noticed anything at 7.5
restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
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the appetite effect faded for me around 15 months and going up fixed it for a while
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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thats STEP 1
did the STEP 4 withdrawal arm show what i think it showed
vial units and pen clicks are different systems, mixing the two is how people end up wrong, from memory
the plateau hit me at 5 weeks and moved again about a month later without a dose change
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does moving my dose day by two days matter with a seven day half life
my Medutest report on the QSC vial came back 99.4 against a certificate saying 98.1
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SELECT wasnt weight
slightly off topic but is the plateau at 17 weeks normal or am i doing something wrong
lost about 26kg on the low doses before i even got to 1, which surprised me
i stayed on 1.7 for 17 months and never went to 2.4, appetite was already where i needed it
plateaus move
how did people handle the jump from 1 to 1.7
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15 months at 2.4 and the honest summary is diminishing returns after the first half, i have it written down somewhere
my 40 vial in 2.5ml gives 8mg/ml so 0.25 lands on 12 units, thats why i picked that volume
the long half life flattens the trough more than people expect, i never felt a day seven dip
i held at 0.25 for 3 months and it was the best decision i made
did anyone hold at 7.5 longer than four weeks before going up
not the same trial
is there a reason to hold at 1.7 rather than going to 2.4
does the licensed ceiling for weight differ from the diabetes one
restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
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dose day is sunday for me only because thats when i remember, not because sunday matters
back after 22 months off, do i restart at 0.25 or somewhere higher
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
STEP 1 ran to 68 weeks. thats the one everyone half remembers
anyone gone from 2.5 straight to 5 or is that too big a jump
slower worked better
£55 a month for compounded against what brand costs locally is why most people here use vials
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held there too