brand vs compounded, is there a difference people can actually feel
#semaglutide 2026-04-05
Sunday79 messages14 participantstimes are UTC
Highlights from this day
- wren_weighs_in — while im here my PeptideMeter report on the GGPeps vial came back 99.2 against a certificate saying 97.4 20:51
- wren_weighs_in — restarted after 26 months off at a low dose and the nausea arrived exactly like the first time 20:54
- VialBot — Reminder set. I will post here in 6 days. 22:30
- VialBot — Assay note: WXT lot A-2601 reported at 99.2% of label content. 23:06
- VialBot — Assay note: SGN lot SG-1177 reported at 97.4% of label content. 23:32
what did SELECT actually measure, i see it quoted for everything
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
is 2.4 the top or do people go past it
same dose day
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plateaus move
give it four weeks
moving my dose day by a day or two never did anything noticeable for me, thats just me
is the plateau usually appetite coming back or just the scale stopping
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP is several trials, so saying STEP said x is usually wrong without a number after it
did anybody find a difference between GGPeps and pharmacy at the same 0.25
did anyone titrate slower than four weeks a step and how did that go
seven days ish
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
[edited]while im here my PeptideMeter report on the GGPeps vial came back 99.2 against a certificate saying 97.4
restarted after 26 months off at a low dose and the nausea arrived exactly like the first time
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SELECT wasnt weight
2.4 is the ceiling
the appetite effect faded for me around 16 months and going up fixed it for a while
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dose day is sunday for me only because thats when i remember, not because sunday matters
whats the actual licensed ceiling, i keep seeing different numbers
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
vial units and pen clicks are different systems, mixing the two is how people end up wrong
unrelated but does the seven day half life mean the last two days are weaker
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, i think
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held there too
while im here does the licensed ceiling for weight differ from the diabetes one
steady state takes weeks
thats STEP 1
slower worked better
how long till steady state, ive read the half life is about a week
coming back to this was STEP 1 the one that ran to 68 weeks or am i mixing them up
slightly off topic but £72 a month for compounded against what brand costs locally is why most people here use vials
does anyone actually run a five week step instead of four
went too fast once
im at 12 and stuck, did anyone break a plateau without going up
i dont think the plateau is a dose problem most of the time, but i cant prove that
im 11 months in at 7.5 and the appetite effect faded, is that a thing
anyone compared their 2.5 vial dosing against the pen increments
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
compounded and brand felt the same to me at 12, which is one person and nothing more
mine faded too
i held at 7.5 for 3 months and it was the best decision i made
does moving my dose day by two days matter with a seven day half life
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
my 5 vial in 2ml gives 2.5mg/ml so 2.5 lands on 40 units, thats why i picked that volume
is there a reason to hold at 1.7 rather than going to 2.4
vial units and pen clicks are different systems, mixing the two is how people end up wrong, still working it out
vials not pens here
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
not the same trial
held at 1.7 and lost 80lb over 6 months, slower than the trials and fine by me
[edited]STEP 1 ran to 68 weeks. thats the one everyone half remembers
how did people handle the jump from 1 to 1.7
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
lost about 32kg on the low doses before i even got to 1, which surprised me
SELECT wasnt weight
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
Reminder set. I will post here in 6 days.
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five week steps worked better for me than four, purely on how the second week felt
the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point
is the plateau at 27 weeks normal or am i doing something wrong
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the plateau hit me at 5 weeks and moved again about a month later without a dose change
how many weeks before you noticed anything at 10
how long did the first 33kg take for people at the low doses
i stayed on 1.7 for 6 months and never went to 2.4, appetite was already where i needed it
STEP 1 ran to 68 weeks. thats the one everyone half remembers
*week 27 not week 3
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
my dose day drifted from friday to sunday, does that reset anything
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Assay note: WXT lot A-2601 reported at 99.2% of label content.
did anyone hold at 1 longer than four weeks before going up
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
back after 11 months off, do i restart at 0.25 or somewhere higher
Assay note: SGN lot SG-1177 reported at 97.4% of label content.
2.4 is the ceiling
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4 months at 2.4 and the honest summary is diminishing returns after the first half
plateaus move