slightly off topic but 5 months at 2.4 and the honest summary is diminishing returns after the first half
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#semaglutide 2026-04-19
Sunday77 messages11 participantstimes are UTC
Highlights from this day
- pbs_pip — ok so my 20 vial in 3ml gives 4mg/ml so 10 lands on 30 units, thats why i picked that volume, thats just me 15:06
- surpass_two — i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it 15:30
- surpass_two — my VendorInvestigate report on the JEEP vial came back 96.8 against a certificate saying 97.4 17:18
- underfill_uma — £38 a month for compounded against what brand costs locally is why most people here use vials 18:45
- swab_dry_first — compounded and brand felt the same to me at 10, which is one person and nothing more 19:44
Reminder for plus_sixteen: dose day is today. Set 2 days ago.
genuine question STEP is several trials, so saying STEP said x is usually wrong without a number after it
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right so compounded and brand felt the same to me at 7.5, which is one person and nothing more
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ok so my 20 vial in 3ml gives 4mg/ml so 10 lands on 30 units, thats why i picked that volume, thats just me
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steady state takes weeks
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
does moving my dose day by two days matter with a seven day half life
i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
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SELECT wasnt weight
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
i held at 12 for 5 months and it was the best decision i made, not advice obviously
anyone gone from 1.7 straight to 0.25 or is that too big a jump
held there too
seven days ish
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thats STEP 1
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
the long half life flattens the trough more than people expect, i never felt a day seven dip
ok so lost about 21kg on the low doses before i even got to 1, which surprised me
i dont think the plateau is a dose problem most of the time, but i cant prove that
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, still working it out
mine faded too
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
is the plateau at 34 weeks normal or am i doing something wrong
give it four weeks
did the STEP 4 withdrawal arm show what i think it showed
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not the same trial
was STEP 1 the one that ran to 68 weeks or am i mixing them up
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe appetite effect faded for me around 25 months and going up fixed it for a while
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held at 2 and lost 37lb over 7 months, slower than the trials and fine by me
genuine question five week steps worked better for me than four, purely on how the second week felt, thats just me
vial units and pen clicks are different systems, mixing the two is how people end up wrong
restarted after 11 months off at a low dose and the nausea arrived exactly like the first time, thats just me
how did people handle the jump from 1 to 1.7
my VendorInvestigate report on the JEEP vial came back 96.8 against a certificate saying 97.4
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
while im here how long till steady state, ive read the half life is about a week
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
dose day is sunday for me only because thats when i remember, not because sunday matters
the plateau hit me at 18 weeks and moved again about a month later without a dose change
im 25 months in at 12 and the appetite effect faded, is that a thing
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
slower worked better
STEP 1 ran to 68 weeks. thats the one everyone half remembers
did anyone titrate slower than four weeks a step and how did that go
is there a reason to hold at 1.7 rather than going to 2.4
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went too fast once
does the licensed ceiling for weight differ from the diabetes one
2.4 is the ceiling
what did SELECT actually measure, i see it quoted for everything
does anyone actually run a five week step instead of four
same dose day
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🙏3🔥17
quick one STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
vials not pens here
moving my dose day by a day or two never did anything noticeable for me
seven days ish
went too fast once
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SELECT wasnt weight, thats one data point
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, take that with a pinch of salt
[edited]is 2.4 the top or do people go past it
plateaus move
vials not pens here
[edited]did anyone hold at 0.5 longer than four weeks before going up
did anybody find a difference between KP and pharmacy at the same 5
£38 a month for compounded against what brand costs locally is why most people here use vials
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg✅12🤝16
anyone compared their 5 vial dosing against the pen increments
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
while im here my dose day drifted from friday to sunday, does that reset anything
does the seven day half life mean the last two days are weaker
compounded and brand felt the same to me at 10, which is one person and nothing more
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how many weeks before you noticed anything at 0.5
thats STEP 1
steady state takes weeks
how long did the first 9kg take for people at the low doses