FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
21 months at 2.4 and the honest summary is diminishing returns after the first half
#semaglutide 2026-04-22
Wednesday27 messages5 participantstimes are UTC
Highlights from this day
- truncation_tru — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 21 months at 2.4 and the honest summary is diminishing returns after the… 17:08
- truncation_tru — STEP is several trials, so saying STEP said x is usually wrong without a number after it 17:40
- truncation_tru — slightly off topic but SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 18:10
- truncation_tru — update on the earlier thing im at 1.7 and stuck, did anyone break a plateau without going up going slow cost me nothing except time and saved me two bad weeks, thats… 19:02
- truncation_tru — anyone compared their 2 vial dosing against the pen increments the plateau hit me at 15 weeks and moved again about a month later without a dose change 20:00
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
steady state takes weeks
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went too fast once
thats STEP 1
SELECT wasnt weight
anyone gone from 7.5 straight to 0.5 or is that too big a jump
$38 a month for compounded against what brand costs locally is why most people here use vials
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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STEP 1 ran to 68 weeks. thats the one everyone half remembers, i have it written down somewhere
held at 5 and lost 48lb over 7 months, slower than the trials and fine by me
11 months at 2.4 and the honest summary is diminishing returns after the first half
how did people handle the jump from 1 to 1.7
slightly off topic but SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
is the plateau usually appetite coming back or just the scale stopping
i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
update on the earlier thing im at 1.7 and stuck, did anyone break a plateau without going up
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
back after 19 months off, do i restart at 0.25 or somewhere higher
does the seven day half life mean the last two days are weaker
moving my dose day by a day or two never did anything noticeable for me, thats just me
im 20 months in at 2.5 and the appetite effect faded, is that a thing
i dont think the plateau is a dose problem most of the time, but i cant prove that
is 2.4 the top or do people go past it
anyone compared their 2 vial dosing against the pen increments
the plateau hit me at 15 weeks and moved again about a month later without a dose change