the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
#semaglutide 2026-05-04
Monday27 messages5 participantstimes are UTC
Highlights from this day
- bram_begins — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 20:44
- bram_begins — is the plateau usually appetite coming back or just the scale stopping 20:45
- marrow.mod — does the seven day half life mean the last two days are weaker 20:52
- marrow.mod — how did people handle the jump from 1 to 1.7 20:59
- marrow.mod — compounded and brand felt the same to me at 2, which is one person and nothing more 21:31
steady state takes weeks
lot-log.csv
659 rows · not retained in the public archive
dose day is sunday for me only because thats when i remember, not because sunday matters
not the same trial
😂3
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
half life is about a week so youre roughly four to five weeks to steady state on any new dose, from memory
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
went too fast once
i stayed on 1.7 for 22 months and never went to 2.4, appetite was already where i needed it
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
same dose day
does the licensed ceiling for weight differ from the diabetes one
how many weeks before you noticed anything at 1
did anybody find a difference between SWB and pharmacy at the same 0.25
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
🎉1❤️18
is the plateau usually appetite coming back or just the scale stopping
👀1❤️6
restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
does the seven day half life mean the last two days are weaker
🤝11
how did people handle the jump from 1 to 1.7
💀9❤️1
slower worked better
moving my dose day by a day or two never did anything noticeable for me
compounded and brand felt the same to me at 2, which is one person and nothing more
✅11🤝9🎉16
back after 23 months off, do i restart at 0.25 or somewhere higher
⚠️1
does moving my dose day by two days matter with a seven day half life
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing