coming back to this went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
#semaglutide 2026-05-20
Wednesday54 messages12 participantstimes are UTC
Highlights from this day
the plateau hit me at 22 weeks and moved again about a month later without a dose change
restarted after 26 months off at a low dose and the nausea arrived exactly like the first time
how long did the first 38kg take for people at the low doses
does moving my dose day by two days matter with a seven day half life
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my 30 vial in 0.5ml gives 2.5mg/ml so 2.4 lands on 20 units, thats why i picked that volume
held there too
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2.4 is the ceiling
plateaus move
[edited]if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, someone check my working
thats STEP 1
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
slightly off topic but im at 0.5 and stuck, did anyone break a plateau without going up
i stayed on 1.7 for 5 months and never went to 2.4, appetite was already where i needed it
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the appetite effect faded for me around 18 months and going up fixed it for a while
[edited]give it four weeks
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genuine question licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
dose day is sunday for me only because thats when i remember, not because sunday matters
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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mine faded too
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
4 months at 2.4 and the honest summary is diminishing returns after the first half
sorry to jump in changed my mind on the four week rule, i think it depends entirely on how the current dose feels
vials not pens here
Reminder for related_subs: dose day is today. Set 9 days ago.
sedge_sourcesgenuine question licensed ceiling for weight is 2.4 weekly, anything above that is not…
im 7 months in at 2.4 and the appetite effect faded, is that a thing
£120 a month for compounded against what brand costs locally is why most people here use vials
five week steps worked better for me than four, purely on how the second week felt
went too fast once
how did people handle the jump from 1 to 1.7
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seven days ish
SELECT wasnt weight
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compounded and brand felt the same to me at 5, which is one person and nothing more
steady state takes weeks
is the plateau at 12 weeks normal or am i doing something wrong
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back after 10 months off, do i restart at 0.25 or somewhere higher
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anyone gone from 7.5 straight to 15 or is that too big a jump
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
moving my dose day by a day or two never did anything noticeable for me, take that with a pinch of salt
the long half life flattens the trough more than people expect, i never felt a day seven dip
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
not the same trial
slower worked better
not the same trial
STEP 1 ran to 68 weeks. thats the one everyone half remembers
[edited]brand vs compounded, is there a difference people can actually feel
how long till steady state, ive read the half life is about a week
the long half life flattens the trough more than people expect, i never felt a day seven dip
went too fast once
slightly off topic but i dont think the plateau is a dose problem most of the time, but i cant prove that, ill dig out the number
STEP 1 ran to 68 weeks. thats the one everyone half remembers
is 2.4 the top or do people go past it
does anyone actually run a five week step instead of four
i held at 12 for 2 months and it was the best decision i made, happy to be corrected