plateaus move
#semaglutide 2026-06-04
Thursday24 messages4 participantstimes are UTC
Highlights from this day
- egfr_ed — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, anyway my plateau was the scale stopping while appetite stayed… 15:40
- surpass_two — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 16:49
- peak_split — moving my dose day by a day or two never did anything noticeable for me 17:49
- surpass_two — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere 18:37
i held at 10 for 9 months and it was the best decision i made, i have it written down somewhere
the plateau hit me at 13 weeks and moved again about a month later without a dose change
steady state takes weeks
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, anyway
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
is the plateau at 18 weeks normal or am i doing something wrong
🙏2
mine faded too
23 months at 2.4 and the honest summary is diminishing returns after the first half
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
what did SELECT actually measure, i see it quoted for everything
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
went too fast once
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
🙏1🧪11
does anyone actually run a five week step instead of four
STEP 1 ran to 68 weeks. thats the one everyone half remembers
half life is about a week so youre roughly four to five weeks to steady state on any new dose, take that with a pinch of salt
held at 2.5 and lost 69lb over 9 months, slower than the trials and fine by me
moving my dose day by a day or two never did anything noticeable for me
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgnot the same trial
held there too
STEP is several trials, so saying STEP said x is usually wrong without a number after it
my 5 vial in 2.5ml gives 4mg/ml so 10 lands on 8 units, thats why i picked that volume
slower worked better
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere