changed my mind on the four week rule, i think it depends entirely on how the current dose feels
#semaglutide 2026-06-20
- bea_reconstitutes — half life is about a week so youre roughly four to five weeks to steady state on any new dose 14:40
- bea_reconstitutes — lost about 25kg on the low doses before i even got to 1, which surprised me going slow cost me nothing except time and saved me two bad weeks, thats my whole… 14:58
- coa_or_cope — my Medutest report on the Homopeptide vial came back 99 against a certificate saying 96.8 16:10
half life is about a week so youre roughly four to five weeks to steady state on any new dose
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
my dose day drifted from friday to sunday, does that reset anything
24 months at 2.4 and the honest summary is diminishing returns after the first half
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
lost about 25kg on the low doses before i even got to 1, which surprised me
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, for what its worth
the plateau hit me at 23 weeks and moved again about a month later without a dose change
did anyone titrate slower than four weeks a step and how did that go
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, ymmv
STEP 1 ran to 68 weeks. thats the one everyone half remembers
my Medutest report on the Homopeptide vial came back 99 against a certificate saying 96.8
sorry to jump in i stayed on 1.7 for 19 months and never went to 2.4, appetite was already where i needed it, from memory
how long did the first 29kg take for people at the low doses
how many weeks before you noticed anything at 1.7
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
restarted after 14 months off at a low dose and the nausea arrived exactly like the first time
anyone gone from 0.5 straight to 1.7 or is that too big a jump
how long till steady state, ive read the half life is about a week