not the same trial
Thread · #semaglutide · 2026-03-05
did anyone hold at 2.5 for longer
Spun off from a message in #semaglutide on 2026-03-05. 16 messages, 4 participants.
The message this came from
- ghent_gradient — did anyone hold at 2.5 for longer than the schedule suggested and regret it, anyone 21:44
did anyone hold at 0.25 longer than four weeks before going up
that was water
a hold is a decision. holding at 0.5 for six months because it works is not failing to progress
on the ladder as tolerability again the ladder in the trials is a tolerability schedule and it has been read as a target ever since, which is a shame
nothing i did on the way up was faster than the label, i simply did not want to do the second week twice
the second year was much less eventful than the first, which is not what i expected going in
score out of five
not a weight result
📉12💀1
week 30 at 10 and compounded and branded material is a supply question and a documentation question, not a pharmacology one, in the population they studied
on the ladder the trial curves flatten around the same place mine did, which surprised me more than it should have, four week average, not weekly
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, the trial schedule was about tolerability
did anyone titrate slower than four weeks a step and how did that go, or should i ask this elsewhere
checking i am not mad i stopped at 5 and stayed there 10 months because it was doing what i wanted it to do
the fade again
👍4🔥4
my clinician was fine with me going slower than the label ladder, and that was a conversation rather than a decision i made alone, thats one person over three years