trial reading the trial curves flatten around the same place mine did, which surprised me more than it should have
Thread · #semaglutide · 2026-03-27
the trial escalation was a tolerability schedule
Spun off from a message in #semaglutide on 2026-03-27. 14 messages, 2 participants.
The message this came from
- leeds_ledger — the trial escalation was a tolerability schedule. it was never a statement about how fast you should go, for me anyway 20:02
plotting a year of this the ladder in the trials is a tolerability schedule and it has been read as a target ever since, which is a shame
a missed day is fine
📈7
less eventful
i logged nausea as a score out of five and the pattern became obvious in a way the words never managed
what happens to the numbers when people stop, in the trials rather than in here, if anyone has a number
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week 33 at 1 and SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, the trial schedule was about tolerability
not a target
about the food noise the difference between my best week and my worst week at one dose is bigger than any step change i ever made, day six fade, for some people
🔥7
five week steps worked better for me than four, purely on how the second week felt
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
sleep is back
for the sema notes i tracked weekly for two years and the trend only ever made sense at a four week rolling average