i logged nausea as a score out of five

i stopped at 1.7 and never found a reason to go higher, and my notes say the same thing three years running, SELECT was outcomes, not weight

the long half life flattens the trough more than people expect, i never felt a day seven dip, happy to be shown otherwise

some people never feel a fade and some feel it every week, both are in this channel and both are logging honestly

the trial escalation was a tolerability schedule. it was never a statement about how fast you should go, the ceiling is where they stopped

half life is about a week so youre roughly four to five weeks to steady state on any new dose, in the population they studied

the difference between my best week and my worst week at one dose is bigger than any step change i ever made, happy to be shown otherwise

i asked for the vial rather than the pen for cost reasons and the arithmetic became my problem, which is a fair trade

saving that, day two here too

what happened for people who sat at a lower step for a very long time

circling back five week steps worked better for me than four, purely on how the second week felt, week to week noise is bigger

nausea at a new step usually settles inside two weeks. nausea that does not is worth a conversation with a prescriber, that is my read of the paper

2.4 is the ceiling

sorry to jump in the first week back after a break hits harder for me than any step ever did, the ceiling is where they stopped

the day either side of the interval has never mattered for me and the half life makes that unsurprising, roughly

SELECT wasnt weight