a few hours at room temperature is almost certainly nothing. a week is a different conversation
#storage-coldchain 2025-03-15
Saturday40 messages6 participantstimes are UTC
Highlights from this day
- logrotate — is a five pound fridge thermometer actually worth it reconstituted solution is the fragile part. that is where the cold chain actually earns its keep 14:45
- bea_reconstitutes — a cooler with two gel packs held under eight degrees for eleven hours on a drive 15:24
- u100_pat — buy a thermometer. mine reads 6.2 on the door and two degrees lower at the back 17:34
- lyophile_liv — i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine 18:39
hand luggage
is a five pound fridge thermometer actually worth it
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
janoshik-d-0718.pdf
2 pages · 203 KB · not retained in the public archive
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freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
i left it out overnight by accident, bin it or use it
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best travel setup for 14 days away with vials
how do you keep it cold on a long drive in summer
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
two to eight
a cooler with two gel packs held under eight degrees for eleven hours on a drive
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
update from 4 months ago: replaced the fridge, temperature is stable, no more anxiety
sorry to jump in the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
cold pack arrived completely liquid, does that mean anything
power cut for 4 hours, fridge stayed shut, am i fine
bea_reconstitutessorry to jump in the practical risk in winter shipping is freezing, and in summer it…
my fridge is running at 5.6, is that out of range
not the door
thats fine
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my fridge is 6.2
lyophilised at room temp for 23 days in transit, worried or not
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i keep everything at the back of the middle shelf, never the door
powder is robust
unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
is there a difference in stability between the compounds
buy a thermometer
for flying, hand luggage every time. the hold is not temperature controlled the way people assume
do you keep the unopened vials and the in-use one in the same place
if you are worried after a bad transit, test it. that is what the testing channels are for
buy a thermometer. mine reads 6.2 on the door and two degrees lower at the back
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how long is reconstituted actually good for at room temperature
does the fridge in a hotel room count as a fridge
how cold is too cold, can it actually freeze in a normal fridge
the vial that visibly changed after a warm transit was the one that had already been reconstituted
what temperature does a domestic fridge door actually swing to
gel packs
anyone tested a vial before and after a bad transit
coming back after 13 months, is the pinned storage table still current
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i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
right so lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
test it
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
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