test it
#storage-coldchain 2025-06-24
Tuesday38 messages8 participantstimes are UTC
Highlights from this day
- dorm_fridge — i keep everything at the back of the middle shelf, never the door 18:18
- plateau_pen — lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear light exposure matters much less than temperature for these. i… 18:40
- brisbane_bac — cold pack arrived completely liquid, does that mean anything 21:54
- truncation_tru — reconstituted solution is the fragile part. that is where the cold chain actually earns its keep 21:56
- quiet.hours — genuine question two to eight degrees. most domestic fridge doors are not in that range and people do not check 22:52
do i need to worry about light exposure or is that overthinking
*that should say weekly
powder is robust
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hand luggage
Digest for the week of 2024-12-12 has been published.
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
buy a thermometer
light exposure matters much less than temperature for these. i still keep them in the carton
i keep everything at the back of the middle shelf, never the door
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a liquid cold pack tells you it was above freezing, not that your vial cooked
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
light exposure matters much less than temperature for these. i still keep them in the carton
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nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
the door swings four or five degrees every time somebody opens it. the back barely moves
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door shelf or back of the fridge
19:08quiet.hours pinned a message to this channel
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
slightly off topic but power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well
buy a thermometer. mine reads 3.1 on the door and two degrees lower at the back
what temperature does a domestic fridge door actually swing to
solution is not
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follow up i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct, take that with a pinch of salt
a cooler with two gel packs held under eight degrees for eleven hours on a drive
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
parcel sat in a hot mailbox for 9 hours, is it dead
janoshik-b-0114.pdf
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is there a difference in stability between the compounds
anyone had a vial visibly change after a warm transit
back of the fridge
i log the fridge temperature daily and the room has never let me forget it
update from 19 months ago: replaced the fridge, temperature is stable, no more anxiety
if you are worried after a bad transit, test it. that is what the testing channels are for
cold pack arrived completely liquid, does that mean anything
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log it
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reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
how do you keep it cold on a long drive in summer
do you keep the unopened vials and the in-use one in the same place
genuine question two to eight degrees. most domestic fridge doors are not in that range and people do not check
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