for the archive the door swings four or five degrees every time somebody opens it. the back barely moves
#storage-coldchain 2025-08-30
Saturday18 messages3 participantstimes are UTC
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what temperature does a domestic fridge door actually swing to
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
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solution is not
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how long is reconstituted actually good for at room temperature
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thats fine
a few hours at room temperature is almost certainly nothing. a week is a different conversation, your mileage will differ
my fridge is 7.4
the vial that visibly changed after a warm transit was the one that had already been reconstituted
two to eight degrees. most domestic fridge doors are not in that range and people do not check
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
two to eight
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
is there a difference in stability between the compounds
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how do you keep it cold on a long drive in summer
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