#storage-coldchain 2025-09-21

test it

ok so do you log the fridge temperature or is that too far

the vial that visibly changed after a warm transit was the one that had already been reconstituted, ill dig out the number

i would bin it

i have never had a lyophilised vial fail after a warm transit and i have had some bad ones

my fridge is running at 3.1, is that out of range

Inter-lab diff for lot B-0329: 96.8% vs 99%. Within expected range.

lyophilised at room temp for 11 days in transit, worried or not

i left it out overnight by accident, bin it or use it

powder is robust

for the archive nobody here can tell you a vial is safe. we can tell you what has and has not survived for us, thats one data point
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway

a cooler with two gel packs held under eight degrees for eleven hours on a drive

the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in

two to eight degrees. most domestic fridge doors are not in that range and people do not check

back of the fridge

for flying, hand luggage every time. the hold is not temperature controlled the way people assume

solution is not

hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct

i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine

best travel setup for 8 days away with vials

the door swings four or five degrees every time somebody opens it. the back barely moves

a liquid cold pack tells you it was above freezing, not that your vial cooked

parcel sat in a hot mailbox for 8 hours, is it dead

i would use it

thats fine

update from 25 months ago: replaced the fridge, temperature is stable, no more anxiety, anyway

i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why

not the door

freeze thaw cycling is the risk, not one freeze. that is my read of it anyway

log it

thats fine

follow up light exposure matters much less than temperature for these. i still keep them in the carton

does the fridge in a hotel room count as a fridge

update on the earlier thing reconstituted solution is the fragile part. that is where the cold chain actually earns its keep, anyway

freeze thaw cycling is the risk, not one freeze. that is my read of it anyway