unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
#storage-coldchain 2025-09-28
Sunday35 messages7 participantstimes are UTC
Highlights from this day
- ferritin_fay — i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why 21:11
- ferritin_fay — sorry to jump in a liquid cold pack tells you it was above freezing, not that your vial cooked 22:50
- typosquat_tay — a cooler with two gel packs held under eight degrees for eleven hours on a drive 22:53
thats fine
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reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
how cold is too cold, can it actually freeze in a normal fridge
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
how do you keep it cold on a long drive in summer
two to eight degrees. most domestic fridge doors are not in that range and people do not check
anyone tested a vial before and after a bad transit
coming back after 3 months, is the pinned storage table still current
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
follow up do i need to worry about light exposure or is that overthinking
for the archive for flying, hand luggage every time. the hold is not temperature controlled the way people assume
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
i would use it
i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
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back of the fridge
i left it out overnight by accident, bin it or use it
update on the earlier thing i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
a few hours at room temperature is almost certainly nothing. a week is a different conversation
test it
i would bin it
follow up does the fridge in a hotel room count as a fridge
how long is reconstituted actually good for at room temperature
is a five pound fridge thermometer actually worth it
light exposure matters much less than temperature for these. i still keep them in the carton, ymmv
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
log it
lyophilised at room temp for 20 days in transit, worried or not
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
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the door swings four or five degrees every time somebody opens it. the back barely moves, ymmv
solution is not
buy a thermometer. mine reads 4 on the door and two degrees lower at the back, thats just me
freeze debate again
update from 10 months ago: replaced the fridge, temperature is stable, no more anxiety
[edited]two to eight
sorry to jump in a liquid cold pack tells you it was above freezing, not that your vial cooked
mon 4.1 / door 7.2
tue 4.0 / door 7.8
wed 4.2 / door 6.9
thu 3.9 / door 7.4
fri 4.1 / door 8.1 <- shopping day
sat 4.3 / door 7.0
sun 4.0 / door 6.8a cooler with two gel packs held under eight degrees for eleven hours on a drive
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