#storage-coldchain 2025-11-22

Saturday47 messages11 participantstimes are UTC

Highlights from this day

hair_month_four — light exposure matters much less than temperature for these. i still keep them in the carton 21:34
acetate_ash — do i need to worry about light exposure or is that overthinking 21:47
fake_tracking — coming back after 25 months, is the pinned storage table still current 22:53

is a five pound fridge thermometer actually worth it

a few hours at room temperature is almost certainly nothing. a week is a different conversation, your mileage will differ

calgary_cold 21:04

back of the fridge

ferritin_fay 21:07

log it

does anyone freeze reconstituted vials or is that madness

calgary_cold 21:13

not the freezer

thats fine

mon  4.1 / door 7.2
tue  4.0 / door 7.8
wed  4.2 / door 6.9
thu  3.9 / door 7.4
fri  4.1 / door 8.1   <- shopping day
sat  4.3 / door 7.0
sun  4.0 / door 6.8

🎉1

acetate_ash 21:17

the vial that visibly changed after a warm transit was the one that had already been reconstituted

solution is not

fake_tracking 21:22

power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well

hair_month_four 21:25

update from 15 months ago: replaced the fridge, temperature is stable, no more anxiety

VialBotbot21:29

Recon calculator: 20mg in 1ml = 2mg/ml.

hair_month_four 21:33

quick one parcel sat in a hot mailbox for 6 hours, is it dead

light exposure matters much less than temperature for these. i still keep them in the carton

🧊12🤝12👍3

two to eight

still_here_2024 21:39

flying with vials, hand luggage or checked

acetate_ash 21:43

does the amber vial thing matter or is it marketing

do i need to worry about light exposure or is that overthinking

mon  4.1 / door 7.2
tue  4.0 / door 7.8
wed  4.2 / door 6.9
thu  3.9 / door 7.4
fri  4.1 / door 8.1   <- shopping day
sat  4.3 / door 7.0
sun  4.0 / door 6.8

✅2📈1

calgary_cold 21:51

genuine question reconstituted solution is the fragile part. that is where the cold chain actually earns its keep

i would use it

🔥13💀10

unopened and in-use in the same place is fine. just keep the in-use one where you can reach it

fake_tracking 21:57

i would bin it

calgary_cold 22:01

lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear

slightly off topic but is there a difference in stability between the compounds

acetate_ash 22:06

a liquid cold pack tells you it was above freezing, not that your vial cooked

fake_tracking 22:11

nobody here can tell you a vial is safe. we can tell you what has and has not survived for us

ferritin_fay 22:16

buy a thermometer. mine reads 4 on the door and two degrees lower at the back

two to eight degrees. most domestic fridge doors are not in that range and people do not check

cleo_tests 22:21

a cooler with two gel packs held under eight degrees for eleven hours on a drive

Condition	Lyophilised	Reconstituted
2-8 °C	fine, long term	fine, weeks
Room temp, days	fine in every report here	reported fine, shorter
Room temp, weeks	reported fine	do not
Warm transit, 30 °C+	no failure logged	one visible degradant peak
Frozen once	fine	contested, no consensus
Freeze-thaw cycled	fine	the room says no

acetate_ash do i need to worry about light exposure or is that overthinking

cleo_tests 22:22

i log the fridge temperature daily and the room has never let me forget it

hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct

LC_MS_Lenalab22:25

test it

💀2🧪5

door shelf or back of the fridge

ferritin_fay 22:29

my fridge is 4.8

✅8

calgary_cold 22:35

for flying, hand luggage every time. the hold is not temperature controlled the way people assume

i have never had a lyophilised vial fail after a warm transit and i have had some bad ones

fake_tracking 22:43

not the door

fake_tracking 22:50

the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in

i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
nobody here can tell you a vial is safe. we can tell you what has and has not survived for us

coming back after 25 months, is the pinned storage table still current

🔥11✅5💀15

calgary_cold 22:55

i keep everything at the back of the middle shelf, never the door

cleo_tests 23:05

if you are worried after a bad transit, test it. that is what the testing channels are for, thats one data point

[edited]

fake_tracking not the door

surpass_two 23:06

freezing reconstituted peptide is the one thing this channel has never agreed on

surpass_two 23:19

gel packs

freeze debate again

powder is robust

Condition	Lyophilised	Reconstituted
2-8 °C	fine, long term	fine, weeks
Room temp, days	fine in every report here	reported fine, shorter
Room temp, weeks	reported fine	do not
Warm transit, 30 °C+	no failure logged	one visible degradant peak
Frozen once	fine	contested, no consensus
Freeze-thaw cycled	fine	the room says no

acetate_ash 23:23

i left it out overnight by accident, bin it or use it