how cold is too cold, can it actually freeze in a normal fridge
#storage-coldchain 2026-03-29
Sunday56 messages11 participantstimes are UTC
Highlights from this day
- VialBot — Archive lookup: two_ml_two first appears in this channel on 2026-02-25. 10:03
- lot_number_lou — i log the fridge temperature daily and the room has never let me forget it, we shall see hotel minibars are frequently not cold enough. i take a thermometer, which is… 11:53
- VialBot — Purity check: no report on file for lot A-2601. Nothing logged either way. 12:16
- split_shipment — how long is reconstituted actually good for at room temperature the vial that visibly changed after a warm transit was the one that had already been reconstituted 13:39
- hair_month_four — a cooler with two gel packs held under eight degrees for eleven hours on a drive 15:46
Archive lookup: two_ml_two first appears in this channel on 2026-02-25.
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
i would use it
is a five pound fridge thermometer actually worth it
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in, take that with a pinch of salt
hand luggage
while im here unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
door shelf or back of the fridge
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
gel packs
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine, ymmv
what temperature does a domestic fridge door actually swing to
test it
for flying, hand luggage every time. the hold is not temperature controlled the way people assume
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my fridge is 6.2
back of the fridge
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i log the fridge temperature daily and the room has never let me forget it, we shall see
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
best travel setup for 24 days away with vials
11:55ferrous_ash pinned a message
log it
Purity check: no report on file for lot A-2601. Nothing logged either way.
light exposure matters much less than temperature for these. i still keep them in the carton
do you keep the unopened vials and the in-use one in the same place
freezing reconstituted peptide is the one thing this channel has never agreed on
update from 5 months ago: replaced the fridge, temperature is stable, no more anxiety
do you log the fridge temperature or is that too far
i keep everything at the back of the middle shelf, never the door, take that with a pinch of salt
anyone had a vial visibly change after a warm transit
lyophilised at room temp for 20 days in transit, worried or not
cold pack arrived completely liquid, does that mean anything
i left it out overnight by accident, bin it or use it
how long is reconstituted actually good for at room temperature
the vial that visibly changed after a warm transit was the one that had already been reconstituted
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
two to eight
do i need to worry about light exposure or is that overthinking
i would bin it
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
[edited]i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
does the amber vial thing matter or is it marketing
the door swings four or five degrees every time somebody opens it. the back barely moves
right so freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
if you are worried after a bad transit, test it. that is what the testing channels are for
the vial that visibly changed after a warm transit was the one that had already been reconstituted
not the door
a liquid cold pack tells you it was above freezing, not that your vial cooked
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power cut for 5 hours, fridge stayed shut, am i fine
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anyone tested a vial before and after a bad transit
not the freezer
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power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well
two to eight degrees. most domestic fridge doors are not in that range and people do not check
*that should say weekly
solution is not
for flying, hand luggage every time. the hold is not temperature controlled the way people assume
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear