a few hours at room temperature is almost certainly nothing. a week is a different conversation
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#storage-coldchain 2026-05-22
Friday51 messages11 participantstimes are UTC
Highlights from this day
- brisbane_bac — a few hours at room temperature is almost certainly nothing. a week is a different conversation 13:05
- no_escrow_nate — do you log the fridge temperature or is that too far 14:55
- tokyo_taper — i keep everything at the back of the middle shelf, never the door 15:18
- no_escrow_nate — freeze thaw cycling is the risk, not one freeze. that is my read of it anyway 15:24
- kelp_keeps — i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine freeze thaw cycling is the risk, not one freeze. that is my… 16:23
update on the earlier thing the door swings four or five degrees every time somebody opens it. the back barely moves
[edited]freeze debate again
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
a cooler with two gel packs held under eight degrees for eleven hours on a drive
log it
power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well, take that with a pinch of salt
while im here my fridge is running at 4.8, is that out of range
New independent result logged — QSC, lot F-1330, purity 98.6% (Janoshik).
the vial that visibly changed after a warm transit was the one that had already been reconstituted
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test it
quick one do i need to worry about light exposure or is that overthinking
solution is not
gel packs
buy a thermometer
i would use it
is a five pound fridge thermometer actually worth it
do you log the fridge temperature or is that too far
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lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
i would bin it
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i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
i keep everything at the back of the middle shelf, never the door
[edited]| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
powder is robust
back of the fridge
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
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freezing reconstituted peptide is the one thing this channel has never agreed on
two to eight
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if you are worried after a bad transit, test it. that is what the testing channels are for
how long is reconstituted actually good for at room temperature
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
for flying, hand luggage every time. the hold is not temperature controlled the way people assume
unopened and in-use in the same place is fine. just keep the in-use one where you can reach it, ymmv
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
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i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
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do you keep the unopened vials and the in-use one in the same place
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
*Janoshik not the other one
i log the fridge temperature daily and the room has never let me forget it
how cold is too cold, can it actually freeze in a normal fridge
not the freezer
a liquid cold pack tells you it was above freezing, not that your vial cooked
not the door
my fridge is 4
buy a thermometer. mine reads 4 on the door and two degrees lower at the back
update from 21 months ago: replaced the fridge, temperature is stable, no more anxiety
genuine question two to eight degrees. most domestic fridge doors are not in that range and people do not check
gel packs
coming back to this light exposure matters much less than temperature for these. i still keep them in the carton
thats fine
coming back after 7 months, is the pinned storage table still current