the GI difference held for me right up to 15, which isnt what a couple of people here found
went back to semaglutide after 9 months because the cost difference mattered more than the GI
#tirzepatide 2024-02-19
Monday28 messages6 participantstimes are UTC
Highlights from this day
- food_noise_off — the sweet spot argument is really about effect per side effect, not a magic number 09:03
- food_noise_off — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 09:09
- vial_ledger — does the appetite effect feel different or just stronger 10:00
- vial_ledger — anyone tracked whether the GI difference held at the top doses 12:01
right so why does everyone talk about 7.5 and not 10
checked the units twice
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
is there a reason to titrate slower than the four week schedule
slightly off topic but i went to 15 and came back to 10, more suppression wasnt more useful for me
the sweet spot thing is survivorship, the people it worked for stayed and said so
the switch felt like a step down at first and then caught up around week 29
GIP plus GLP-1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
09:00ferrous_ash pinned a message
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, for what its worth
the sweet spot argument is really about effect per side effect, not a magic number
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i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
[edited]switched last year
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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is the sweet spot argument about effect or about side effects
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
anyone stopped at 10 and stayed there for months
i sat at 7.5 for 13 months and never needed more, which is where the folklore comes from
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
does the appetite effect feel different or just stronger
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right so how did people handle the 2.5 to 5 jump
did anyone go past 15 and was there any point to it
follow up im at 2.4 and thinking about 1.7, did anyone gain anything from that step
anyone tracked whether the GI difference held at the top doses
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titrate slow
same plateau here
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it, thats just me
at 0.5 my appetite is gone entirely, did anyone go down rather than up