the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
#tirzepatide 2024-08-18
Sunday42 messages8 participantstimes are UTC
Highlights from this day
- chaser_chris — i went to 15 and came back to 10, more suppression wasnt more useful for me, your mileage will differ 17:57
- chaser_chris — did anybody switch back to semaglutide after trying this 18:24
- lean_mass_lex — why does everyone talk about 7.5 and not 10 19:47
- lean_mass_lex — does the GIP arm actually explain the easier nausea or is that hand waving 19:59
i went to 15 and came back to 10, more suppression wasnt more useful for me, your mileage will differ
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ok so is there a reason to titrate slower than the four week schedule
im at 0.25 and thinking about 15, did anyone gain anything from that step
SURMOUNT is weight
quick one switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
did anybody switch back to semaglutide after trying this
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restarted at 2.5 after 19 months off and the first two doses reminded me why titration exists
i argued the sweet spot was nonsense and then spent 17 months at 7.5 not needing more
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
genuine question i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from, for what its worth
switched last year
at 15 the GI came back for me, so my easier profile claim only applies below that
whats the top licensed dose, 15 or does it go higher
the 2.5 to 5 step was the roughest one for me and everything after was easier
[edited]no clean conversion
update on the earlier thing went back to semaglutide after 18 months because the cost difference mattered more than the GI
the switch felt like a step down at first and then caught up around week 6
*PeptideMeter not the other one
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
checked the units twice
why does everyone talk about 7.5 and not 10
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does the GIP arm actually explain the easier nausea or is that hand waving
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does switching from semaglutide need a gap or do you just start
titrate slow
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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my Medutest result on a GGPeps vial came in at 99.4 which is why i keep buying from them, n of 1 obviously
the trials titrated every four weeks to a target, most people here stop at whatever works
GIP plus GLP-1
10 was enough
coming off semaglutide, is there a conversion or do i restart at 2.5
anyone stopped at 10 and stayed there for months
[edited]how long before the dual thing was noticeable to you
if youre coming off semaglutide the honest answer is start low and find out, theres no table
the GI difference held for me right up to 15, which isnt what a couple of people here found
whats the plateau pattern here, same as semaglutide or different
easier gi for me
anyone tracked whether the GI difference held at the top doses
folklore probably
start low anyway
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the 5 vial in 2.5ml gives 2.5mg/ml which puts 0.5 on 5 units, nice round numbers
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, n of 1 obviously