no clean conversion
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#tirzepatide 2024-08-25
Sunday30 messages7 participantstimes are UTC
Highlights from this day
- lean_mass_lex — switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it 10:42
- half_life_hal — for the archive 12 did nothing extra over 10 for me and that still holds a year later 11:37
- half_life_hal — the switch felt like a step down at first and then caught up around week 23, thats just me 14:13
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
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is 7.5 really the sweet spot or is that just channel folklore
the 10 vial in 0.5ml gives 8mg/ml which puts 12 on 25 units, nice round numbers
for the archive 12 did nothing extra over 10 for me and that still holds a year later
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quick one licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
switched last year
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how did people handle the 2.5 to 5 jump
is SURMOUNT-OSA the sleep apnoea one
*Medutest not the other one
folklore probably
the sweet spot argument is really about effect per side effect, not a magic number
GIP plus GLP-1
back after 8 months, do i restart at 2.5 or pick up near where i left off
10 was enough
whats the plateau pattern here, same as semaglutide or different
at 15 the GI came back for me, so my easier profile claim only applies below that
i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from
the trials titrated every four weeks to a target, most people here stop at whatever works
does the GIP arm actually explain the easier nausea or is that hand waving
im at 5 and thinking about 7.5, did anyone gain anything from that step
the switch felt like a step down at first and then caught up around week 23, thats just me
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7.5 gang
no gap when i switched, took the last semaglutide dose and started this a week later
easier gi for me
[edited]SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT is weight
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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start low anyway
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
sorry to jump in the 2.5 to 5 step was the roughest one for me and everything after was easier