the trials titrated every four weeks to a target, most people here stop at whatever works
#tirzepatide 2024-09-05
Thursday24 messages6 participantstimes are UTC
Highlights from this day
- gip_glp_gil — slightly off topic but if youre coming off semaglutide the honest answer is start low and find out, theres no table, thats just me 20:32
- gip_glp_gil — is SURMOUNT-OSA the sleep apnoea one 20:52
- glucagon_arm — the sweet spot argument is really about effect per side effect, not a magic number 20:54
- glucagon_arm — slightly off topic but at 15 my appetite is gone entirely, did anyone go down rather than up 21:38
- swab_dry_first — anyone tracked whether the GI difference held at the top doses 22:52
did going from 10 semaglutide to 5 of this feel like a step down for anyone
12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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slightly off topic but if youre coming off semaglutide the honest answer is start low and find out, theres no table, thats just me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
is SURMOUNT-OSA the sleep apnoea one
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the sweet spot argument is really about effect per side effect, not a magic number
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titrate slow
same plateau here
start low anyway
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
restarted at 2.5 after 19 months off and the first two doses reminded me why titration exists, from memory
slightly off topic but at 15 my appetite is gone entirely, did anyone go down rather than up
[edited]lot-log.csv
889 rows · not retained in the public archive
did anybody switch back to semaglutide after trying this
SURMOUNT is weight
switched last year
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
checked the units twice
5 did nothing
anyone tracked whether the GI difference held at the top doses
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does the GIP arm actually explain the easier nausea or is that hand waving
easier gi for me