plateaued at 21 weeks the same way i did on semaglutide, so i doubt its compound specific
[edited]#tirzepatide 2024-10-04
Friday40 messages10 participantstimes are UTC
Highlights from this day
- orfor_watch — anyone got a 10 recon they like for the 15 vials 16:46
- orfor_watch — is there a reason to titrate slower than the four week schedule 17:01
- drawup_dee — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 17:58
- vial_ledger — sorry to jump in the sweet spot thing is survivorship, the people it worked for stayed and said so, i could be wrong 19:15
- non_scale_win — start low anyway, ill dig out the number 20:06
at 15 the GI came back for me, so my easier profile claim only applies below that
[edited]at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
the sweet spot argument is really about effect per side effect, not a magic number
anyone got a 10 recon they like for the 15 vials
janoshik-f-1330.pdf
2 pages · 916 KB · not retained in the public archive
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15 is the top
is there a reason to titrate slower than the four week schedule
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the 15 vial in 2ml gives 4mg/ml which puts 0.25 on 40 units, nice round numbers
New independent result logged — HJ, lot H-2814, purity 98.6% (PeptideMeter).
no gap when i switched, took the last semaglutide dose and started this a week later
SURMOUNT is weight
if youre coming off semaglutide the honest answer is start low and find out, theres no table
no clean conversion
did anybody switch back to semaglutide after trying this
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did, anyway
did anyone go past 15 and was there any point to it
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
10 was enough
follow up i argued the sweet spot was nonsense and then spent 14 months at 7.5 not needing more
€120 for a 2 vial is roughly what ive paid for the last year
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switched last year
12 did nothing extra over 10 for me and that still holds a year later
does the appetite effect feel different or just stronger
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
anyone tracked whether the GI difference held at the top doses
sorry to jump in the sweet spot thing is survivorship, the people it worked for stayed and said so, i could be wrong
im at 0.25 and thinking about 2.5, did anyone gain anything from that step
restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
the trials titrated every four weeks to a target, most people here stop at whatever works
anyone stopped at 10 and stayed there for months
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5 did nothing
Inter-lab diff for lot C-4402: 99.4% vs 96.8%. Within expected range.
coming off semaglutide, is there a conversion or do i restart at 2.5
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start low anyway, ill dig out the number
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40 units of a 10 solution is a lot of volume and i check that one twice every single time
update on the earlier thing is SURMOUNT-OSA the sleep apnoea one
5 was where i first noticed it properly, 2.5 did almost nothing for me
how did people handle the 2.5 to 5 jump
does switching from semaglutide need a gap or do you just start