plateaued at 26 weeks the same way i did on semaglutide, so i doubt its compound specific, thats one data point
#tirzepatide 2024-10-10
Thursday37 messages7 participantstimes are UTC
Highlights from this day
- subq_sy — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 10:21
- VialBot — Verification log updated: TFC — evidence added, status unchanged. 11:25
- u100_pat — 5 was where i first noticed it properly, 2.5 did almost nothing for me 14:52
- VialBot — Assay note: HJ lot H-2814 reported at 97.4% of label content. 15:27
start low anyway
my PeptideMeter result on a WXT vial came in at 98.6 which is why i keep buying from them
did anyone find the GI easier than semaglutide at an equivalent effect
*Janoshik not the other one
5 did nothing
at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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GIP plus GLP-1
coming off semaglutide, is there a conversion or do i restart at 2.5
at 15 the GI came back for me, so my easier profile claim only applies below that
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the sweet spot thing is survivorship, the people it worked for stayed and said so
checked the units twice
Verification log updated: TFC — evidence added, status unchanged.
did anyone go past 15 and was there any point to it
coming back to this i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, i could be wrong
if youre coming off semaglutide the honest answer is start low and find out, theres no table
switched last year
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the 2.5 to 5 step was the roughest one for me and everything after was easier
anyone got a 4 recon they like for the 15 vials
no clean conversion
the GI difference held for me right up to 15, which isnt what a couple of people here found
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i went to 15 and came back to 10, more suppression wasnt more useful for me
7.5 gang
went back to semaglutide after 6 months because the cost difference mattered more than the GI
the two compounds arent interchangeable week for week even if the effect ends up similar
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15 is the top
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why does everyone talk about 7.5 and not 10
5 was where i first noticed it properly, 2.5 did almost nothing for me
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back after 2 months, do i restart at 2.5 or pick up near where i left off
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
whats the plateau pattern here, same as semaglutide or different
Assay note: HJ lot H-2814 reported at 97.4% of label content.
is the sweet spot argument about effect or about side effects
10 was enough
folklore probably