10 was enough
#tirzepatide 2024-10-27
Sunday48 messages11 participantstimes are UTC
Highlights from this day
- salt_bridge — i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more 21:52
- reship_rita — there is no clean conversion between the two, anyone giving you a ratio is guessing 22:23
- thirty_min_wait — i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from 22:34
ok so 40 units of a 5 solution is a lot of volume and i check that one twice every single time
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, ymmv
5 did nothing
Testing queue: 8 submissions open, 69 awaiting dispatch.
easier gi for me
did anybody switch back to semaglutide after trying this
is the 40 vial the common one or do people use 5
same plateau here
SURMOUNT is weight
😂17
titrate slow
went back to semaglutide after 20 months because the cost difference mattered more than the GI, happy to be corrected
i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more
site-rotation-map.png
1000 × 700 · 596 KB · not retained in the public archive
❤️9🤝3
the two compounds arent interchangeable week for week even if the effect ends up similar
folklore probably
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
🧊4
start low anyway
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
whats the top licensed dose, 15 or does it go higher
plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
ok so 12 did nothing extra over 10 for me and that still holds a year later
the GI difference held for me right up to 15, which isnt what a couple of people here found
genuine question how did people handle the 2.5 to 5 jump
the switch felt like a step down at first and then caught up around week 7
7.5 gang
[edited]GIP plus GLP-1
👍9🎉17
checked the units twice
anyone tracked whether the GI difference held at the top doses
[edited]there is no clean conversion between the two, anyone giving you a ratio is guessing
📈11👀6
15 is the top
the sweet spot argument is really about effect per side effect, not a magic number
i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)sorry to jump in is SURMOUNT-OSA the sleep apnoea one
at 7.5 my appetite is gone entirely, did anyone go down rather than up
quick one changed my mind about needing 15, i was chasing a number rather than an outcome
update on the earlier thing my VendorInvestigate result on a QYB vial came in at 99.4 which is why i keep buying from them, anyway
*Janoshik not the other one
held 10 for 24 months and lost 32kg over that stretch, slow and boring and fine
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
why does everyone talk about 7.5 and not 10
🎉1
no gap when i switched, took the last semaglutide dose and started this a week later
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
Purity check: no report on file for lot KP-0925. Nothing logged either way.
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
if youre coming off semaglutide the honest answer is start low and find out, theres no table
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the trials titrated every four weeks to a target, most people here stop at whatever works