i went to 15 and came back to 10, more suppression wasnt more useful for me
🤝15🧪6💀1
#tirzepatide 2025-01-31
Friday44 messages8 participantstimes are UTC
Highlights from this day
- split_dose_sam — i went to 15 and came back to 10, more suppression wasnt more useful for me 11:42
- factory_direct_fi — held 10 for 20 months and lost 28kg over that stretch, slow and boring and fine 13:34
- acetate_ash — the sweet spot thing is survivorship, the people it worked for stayed and said so 17:14
no clean conversion
5 did nothing
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
follow up no gap when i switched, took the last semaglutide dose and started this a week later
the 2.5 to 5 step was the roughest one for me and everything after was easier, take that with a pinch of salt
7.5 gang
SURMOUNT is weight
anyone tracked whether the GI difference held at the top doses
start low anyway
unrelated but whats the top licensed dose, 15 or does it go higher
genuine question restarted at 2.5 after 4 months off and the first two doses reminded me why titration exists
plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific
held 10 for 20 months and lost 28kg over that stretch, slow and boring and fine
✅1🧊13👍7
easier gi for me
❤️10👀17
i sat at 7.5 for 1 months and never needed more, which is where the folklore comes from, from memory
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
anyone got a 10 recon they like for the 15 vials
🔥12😂18
5 was where i first noticed it properly, 2.5 did almost nothing for me
went back to semaglutide after 14 months because the cost difference mattered more than the GI
14:25ferrous_ash pinned a message
GIP plus GLP-1
the 15 vial in 2.5ml gives 5mg/ml which puts 5 on 15 units, nice round numbers
15 is the top
changed my mind about needing 15, i was chasing a number rather than an outcome
the trials titrated every four weeks to a target, most people here stop at whatever works
👍5🔥6
switched last year
Archive lookup: factory_direct_fi first appears in this channel on 2024-04-01.
🧊2😂1
anyone stopped at 10 and stayed there for months
40 units of a 8 solution is a lot of volume and i check that one twice every single time
unrelated but at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, take that with a pinch of salt
16:02ferrous_ash pinned a message
factory_direct_fiwent back to semaglutide after 14 months because the cost difference mattered more…
the switch felt like a step down at first and then caught up around week 10, i think
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
unrelated but 12 did nothing extra over 10 for me and that still holds a year later
titrate slow
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)checked the units twice
[edited]how many weeks at 7.5 before you knew it was enough
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
the sweet spot thing is survivorship, the people it worked for stayed and said so
👀14😂14
unrelated but i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
10 was enough
if youre coming off semaglutide the honest answer is start low and find out, theres no table, not advice obviously
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |