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#tirzepatide 2025-02-09

Sunday29 messages6 participantstimes are UTC
Highlights from this day
  • orfor_watch — 12 did nothing extra over 10 for me and that still holds a year later 18:53
  • orfor_watch — right so the sweet spot argument is really about effect per side effect, not a magic number 19:24
  • VialBot — Batch lookup E-2205: 4 independent reports on file, earliest 2024-07-25. 19:54
TF

switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it

ok so at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

OW

changed my mind about needing 15, i was chasing a number rather than an outcome

no clean conversion

[edited]

right so if youre coming off semaglutide the honest answer is start low and find out, theres no table

does switching from semaglutide need a gap or do you just start

went back to semaglutide after 9 months because the cost difference mattered more than the GI

15 is the top

OW

12 did nothing extra over 10 for me and that still holds a year later

Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.
🧪1🔥9
EE

i sat at 7.5 for 25 months and never needed more, which is where the folklore comes from

OW

right so the sweet spot argument is really about effect per side effect, not a magic number

1🤝9🧊2
VB

Batch lookup E-2205: 4 independent reports on file, earliest 2024-07-25.

OW

coming back to this 40 units of a 10 solution is a lot of volume and i check that one twice every single time

OW

did anyone find the GI easier than semaglutide at an equivalent effect

AO

the two compounds arent interchangeable week for week even if the effect ends up similar

3

the 2.5 to 5 step was the roughest one for me and everything after was easier