the sweet spot thing is survivorship, the people it worked for stayed and said so
#tirzepatide 2025-02-14
Friday24 messages6 participantstimes are UTC
Highlights from this day
- five_mg_ml — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 14:19
- customs_owl — 40 units of a 5 solution is a lot of volume and i check that one twice every single time 14:20
- gip_glp_gil — whats the plateau pattern here, same as semaglutide or different 14:23
- gip_glp_gil — held 10 for 17 months and lost 38kg over that stretch, slow and boring and fine 14:31
- five_mg_ml — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i think 16:23
went back to semaglutide after 2 months because the cost difference mattered more than the GI
*VendorInvestigate not the other one
the sweet spot argument is really about effect per side effect, not a magic number
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
😂2✅4
40 units of a 5 solution is a lot of volume and i check that one twice every single time
⚠️15🔥6✅1
easier gi for me
whats the plateau pattern here, same as semaglutide or different
📉4
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
held 10 for 17 months and lost 38kg over that stretch, slow and boring and fine
🧪5🧊3
how did people handle the 2.5 to 5 jump
titrate slow
12 did nothing extra over 10 for me and that still holds a year later
update on the earlier thing 5 was where i first noticed it properly, 2.5 did almost nothing for me
SURMOUNT is weight
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i think
did anybody switch back to semaglutide after trying this
the switch felt like a step down at first and then caught up around week 15, your mileage will differ
slightly off topic but is the sweet spot argument about effect or about side effects
[edited]*VendorInvestigate not the other one
no clean conversion
quick one plateaued at 27 weeks the same way i did on semaglutide, so i doubt its compound specific
[edited]*week 22 not week 9
did going from 2.5 semaglutide to 5 of this feel like a step down for anyone