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#tirzepatide 2025-02-21

Friday34 messages9 participantstimes are UTC
Highlights from this day
  • surpass_two — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 22:42
  • reship_rita — the sweet spot argument is really about effect per side effect, not a magic number 22:53
  • VialBot — Inter-lab diff for lot B-0329: 96.8% vs 98.6%. Within expected range. 23:04
  • surpass_two — did anyone find the GI easier than semaglutide at an equivalent effect 23:08
ST

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

peptidemeter-summary-d-0718.pdf
2 pages · 886 KB · not retained in the public archive

40 units of a 4 solution is a lot of volume and i check that one twice every single time

5 was where i first noticed it properly, 2.5 did almost nothing for me, thats one data point

im at 5 and thinking about 2.4, did anyone gain anything from that step

🎉1👍8
RR

the sweet spot argument is really about effect per side effect, not a magic number

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.
ST

coming off semaglutide, is there a conversion or do i restart at 2.5

7.5 gang

switched last year

FT

i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more

VB

Inter-lab diff for lot B-0329: 96.8% vs 98.6%. Within expected range.

1😂3
ST

did anyone find the GI easier than semaglutide at an equivalent effect

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.

checked the units twice

no clean conversion

MM

back after 6 months, do i restart at 2.5 or pick up near where i left off

the 20 vial in 1.5ml gives 10mg/ml which puts 5 on 5 units, nice round numbers, ymmv

SURMOUNT is weight

why does everyone talk about 7.5 and not 10

i log everything and my appetite curve looks flatter across the week than my semaglutide log did, happy to be corrected

switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it

how did people handle the 2.5 to 5 jump

EO

while im here at 2.4 my appetite is gone entirely, did anyone go down rather than up

FT

my Medutest result on a JEEP vial came in at 98.6 which is why i keep buying from them

*PeptideMeter not the other one

PB

restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists

FT

plateaued at 22 weeks the same way i did on semaglutide, so i doubt its compound specific

FT

the two compounds arent interchangeable week for week even if the effect ends up similar

anyone stopped at 10 and stayed there for months