there is no clean conversion between the two, anyone giving you a ratio is guessing, i could be wrong
#tirzepatide 2025-03-17
Monday45 messages9 participantstimes are UTC
Highlights from this day
- first_month_fi — i argued the sweet spot was nonsense and then spent 12 months at 7.5 not needing more, for what its worth 22:04
- month_six_me — why does everyone talk about 7.5 and not 10 switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it 23:01
- month_six_me — coming back to this i log everything and my appetite curve looks flatter across the week than my semaglutide log did the sweet spot argument is really about effect… 23:05
- logrotate — the trials titrated every four weeks to a target, most people here stop at whatever works, i have it written down somewhere 23:18
- logrotate — ok so my Janoshik result on a GGPeps vial came in at 99.2 which is why i keep buying from them, i could be wrong 23:21
restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
i went to 15 and came back to 10, more suppression wasnt more useful for me
at 0.25 my appetite is gone entirely, did anyone go down rather than up
same plateau here
10 was enough
anyone tracked whether the GI difference held at the top doses
ok so the switch felt like a step down at first and then caught up around week 16
slightly off topic but 5 was where i first noticed it properly, 2.5 did almost nothing for me
$185 for a 2 vial is roughly what ive paid for the last year
does switching from semaglutide need a gap or do you just start
[edited]i argued the sweet spot was nonsense and then spent 12 months at 7.5 not needing more, for what its worth
folklore probably
switched last year
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
start low anyway
no clean conversion
at 15 the GI came back for me, so my easier profile claim only applies below that
is 7.5 really the sweet spot or is that just channel folklore
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
titrate slow
held 10 for 9 months and lost 31kg over that stretch, slow and boring and fine
5 did nothing
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slightly off topic but whats the plateau pattern here, same as semaglutide or different
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
did anyone find the GI easier than semaglutide at an equivalent effect
did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific
[edited]SURMOUNT is weight
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is the sweet spot argument about effect or about side effects
whats the top licensed dose, 15 or does it go higher
changed my mind about needing 15, i was chasing a number rather than an outcome, someone check my working
why does everyone talk about 7.5 and not 10
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
*Janoshik not the other one
coming back to this i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the sweet spot argument is really about effect per side effect, not a magic number
does the appetite effect feel different or just stronger
anyone got a 10 recon they like for the 2 vials
back after 7 months, do i restart at 2.5 or pick up near where i left off
[edited]the trials titrated every four weeks to a target, most people here stop at whatever works, i have it written down somewhere
ok so my Janoshik result on a GGPeps vial came in at 99.2 which is why i keep buying from them, i could be wrong
GIP plus GLP-1
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the sweet spot argument is really about effect per side effect, not a magic number
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect