SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
#tirzepatide 2025-03-28
Friday41 messages8 participantstimes are UTC
Highlights from this day
- belfast_bac — does the appetite effect feel different or just stronger 09:44
- courier_vs_post — anyone stopped at 10 and stayed there for months 10:56
- chlorhex — the sweet spot thing is survivorship, the people it worked for stayed and said so 11:48
- chlorhex — at 15 the GI came back for me, so my easier profile claim only applies below that 12:23
$72 for a 5 vial is roughly what ive paid for the last year
at 10 my appetite is gone entirely, did anyone go down rather than up
10 was enough
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how many weeks at 7.5 before you knew it was enough
same plateau here
the two compounds arent interchangeable week for week even if the effect ends up similar
15 is the top
does the appetite effect feel different or just stronger
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no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me
the 30 vial in 3ml gives 4mg/ml which puts 0.25 on 40 units, nice round numbers
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
for the archive went back to semaglutide after 19 months because the cost difference mattered more than the GI
is the sweet spot argument about effect or about side effects
the sweet spot argument is really about effect per side effect, not a magic number, still working it out
7.5 gang
titrate slow
follow up changed my mind about needing 15, i was chasing a number rather than an outcome
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
anyone stopped at 10 and stayed there for months
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there is no clean conversion between the two, anyone giving you a ratio is guessing
GIP plus GLP-1
switched last year
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12 did nothing extra over 10 for me and that still holds a year later
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
did anyone go past 15 and was there any point to it
plateaued at 19 weeks the same way i did on semaglutide, so i doubt its compound specific
the sweet spot thing is survivorship, the people it worked for stayed and said so
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how long before the dual thing was noticeable to you
at 15 the GI came back for me, so my easier profile claim only applies below that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
did anyone find the GI easier than semaglutide at an equivalent effect
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists
the GI difference held for me right up to 15, which isnt what a couple of people here found
start low anyway
13:57tenpence pinned a message
easier gi for me
my VendorInvestigate result on a Homopeptide vial came in at 99 which is why i keep buying from them
i log everything and my appetite curve looks flatter across the week than my semaglutide log did