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#tirzepatide 2025-04-07

Monday13 messages3 participantstimes are UTC
Highlights from this day
  • chlorhex — dual agonist, GIP as well as GLP-1, thats the whole difference in one line 16:35
  • knees_first — i sat at 7.5 for 2 months and never needed more, which is where the folklore comes from if youre coming off semaglutide the honest answer is start low and find out,… 16:46
  • knees_first — if youre coming off semaglutide the honest answer is start low and find out, theres no table at 15 the GI came back for me, so my easier profile claim only applies… 16:48
  • knees_first — does switching from semaglutide need a gap or do you just start 17:05
CH

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

Trial scheduleWhat most people here do
Step interval4 weeks, fixed4-12 weeks, on symptoms
Holdingprotocol deviationnormal and expected
Top dosereached by designoften never reached
Coming downnot studiedcommon at maintenance
CH

changed my mind about needing 15, i was chasing a number rather than an outcome

KF

at 10 my appetite is gone entirely, did anyone go down rather than up

i sat at 7.5 for 2 months and never needed more, which is where the folklore comes from
if youre coming off semaglutide the honest answer is start low and find out, theres no table

if youre coming off semaglutide the honest answer is start low and find out, theres no table
at 15 the GI came back for me, so my easier profile claim only applies below that

[edited]

licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
12 did nothing extra over 10 for me and that still holds a year later

KF

right so why does everyone talk about 7.5 and not 10

😂1👀2📈1

does switching from semaglutide need a gap or do you just start

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.

*PeptideMeter not the other one