anyone got a 2.5 recon they like for the 10 vials
#tirzepatide 2025-05-13
Tuesday41 messages10 participantstimes are UTC
Highlights from this day
- wrong_network — if youre coming off semaglutide the honest answer is start low and find out, theres no table 20:15
- first_and_last_four — plateaued at 4 weeks the same way i did on semaglutide, so i doubt its compound specific 21:07
- factory_direct_fi — coming back to this switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it 21:10
5 did nothing
did anyone go past 15 and was there any point to it
the 2.5 to 5 step was the roughest one for me and everything after was easier, for what its worth
same plateau here
at 15 the GI came back for me, so my easier profile claim only applies below that
im at 0.25 and thinking about 12, did anyone gain anything from that step
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)does the GIP arm actually explain the easier nausea or is that hand waving
went back to semaglutide after 26 months because the cost difference mattered more than the GI
my PeptideMeter result on a HJ vial came in at 98.1 which is why i keep buying from them
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
15 is the top
no clean conversion
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
40 units of a 5 solution is a lot of volume and i check that one twice every single time
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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did going from 0.25 semaglutide to 5 of this feel like a step down for anyone
quick one the sweet spot argument is really about effect per side effect, not a magic number
the two compounds arent interchangeable week for week even if the effect ends up similar
back after 20 months, do i restart at 2.5 or pick up near where i left off
i went to 15 and came back to 10, more suppression wasnt more useful for me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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no gap when i switched, took the last semaglutide dose and started this a week later
checked the units twice
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
does switching from semaglutide need a gap or do you just start
changed my mind about needing 15, i was chasing a number rather than an outcome
12 did nothing extra over 10 for me and that still holds a year later
plateaued at 4 weeks the same way i did on semaglutide, so i doubt its compound specific
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5 was where i first noticed it properly, 2.5 did almost nothing for me
coming back to this switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)is the 10 vial the common one or do people use 40
easier gi for me
i sat at 7.5 for 13 months and never needed more, which is where the folklore comes from
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
right so did anyone find the GI easier than semaglutide at an equivalent effect
folklore probably
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
the GI difference held for me right up to 15, which isnt what a couple of people here found