licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)#tirzepatide 2025-05-18
Sunday57 messages11 participantstimes are UTC
Highlights from this day
- warsaw_vial — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 16:46
- slow.taper — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 16:55
- HPLC_Hank — 5 was where i first noticed it properly, 2.5 did almost nothing for me 17:16
- HPLC_Hank — the sweet spot argument is really about effect per side effect, not a magic number, thats one data point 17:20
- nausea_window — checked the units twice, i have it written down somewhere 21:34
anyone got a 4 recon they like for the 15 vials
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more, still working it out
at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win
at 15 the GI came back for me, so my easier profile claim only applies below that
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ymmv
Recon calculator: 5mg in 0.5ml = 8mg/ml.
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
5 was where i first noticed it properly, 2.5 did almost nothing for me
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the 2.5 to 5 step was the roughest one for me and everything after was easier
the sweet spot argument is really about effect per side effect, not a magic number, thats one data point
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how did people handle the 2.5 to 5 jump
checked the units twice
start low anyway
[edited]40 units of a 5 solution is a lot of volume and i check that one twice every single time
at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
ok so the 15 vial in 2ml gives 8mg/ml which puts 1 on 15 units, nice round numbers
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for the archive anyone tracked whether the GI difference held at the top doses
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*VendorInvestigate not the other one
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
went back to semaglutide after 22 months because the cost difference mattered more than the GI
i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from
why does everyone talk about 7.5 and not 10
ok so €38 for a 40 vial is roughly what ive paid for the last year
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
SURMOUNT is weight
does the appetite effect feel different or just stronger
the switch felt like a step down at first and then caught up around week 19
titrate slow
if youre coming off semaglutide the honest answer is start low and find out, theres no table
12 did nothing extra over 10 for me and that still holds a year later
the trials titrated every four weeks to a target, most people here stop at whatever works
5 did nothing
the GI difference held for me right up to 15, which isnt what a couple of people here found, from memory
New independent result logged — TFC, lot B-0114, purity 97.4% (Janoshik).
at 12 my appetite is gone entirely, did anyone go down rather than up
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did anyone find the GI easier than semaglutide at an equivalent effect
there is no clean conversion between the two, anyone giving you a ratio is guessing
my PeptideMeter result on a SSA vial came in at 99.4 which is why i keep buying from them
no gap when i switched, took the last semaglutide dose and started this a week later
does switching from semaglutide need a gap or do you just start
quick one the sweet spot thing is survivorship, the people it worked for stayed and said so
no clean conversion
10 was enough
held 10 for 24 months and lost 14kg over that stretch, slow and boring and fine
easier gi for me
7.5 gang
changed my mind about needing 15, i was chasing a number rather than an outcome
coming back to this dual agonist, GIP as well as GLP-1, thats the whole difference in one line
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific
GIP plus GLP-1
genuine question did anybody switch back to semaglutide after trying this
follow up is the sweet spot argument about effect or about side effects
switched last year
coming back to this back after 17 months, do i restart at 2.5 or pick up near where i left off
at 15 the GI came back for me, so my easier profile claim only applies below that
checked the units twice, i have it written down somewhere
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)15 is the top
the two compounds arent interchangeable week for week even if the effect ends up similar