went back to semaglutide after 6 months because the cost difference mattered more than the GI, happy to be corrected
#tirzepatide 2025-07-19
Saturday61 messages12 participantstimes are UTC
Highlights from this day
- nhs_pathway_nell — whats the top licensed dose, 15 or does it go higher 22:43
- mcg_not_mg — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 22:48
- mg_per_ml — switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it, still working it out 23:30
- mg_per_ml — coming off semaglutide, is there a conversion or do i restart at 2.5 23:33
- night_pin — at 5 my appetite is gone entirely, did anyone go down rather than up 23:55
15 is the top
switched last year
changed my mind about needing 15, i was chasing a number rather than an outcome
easier gi for me
5 did nothing
the switch felt like a step down at first and then caught up around week 34
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at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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no clean conversion
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
titrate slow
unrelated but i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more
i sat at 7.5 for 1 months and never needed more, which is where the folklore comes from
did anyone go past 15 and was there any point to it
sorry to jump in the GI difference held for me right up to 15, which isnt what a couple of people here found
whats the plateau pattern here, same as semaglutide or different
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did anyone find the GI easier than semaglutide at an equivalent effect
is the 15 vial the common one or do people use 30
[edited]the sweet spot argument is really about effect per side effect, not a magic number, ask me again in a month
start low anyway
[edited]SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
checked the units twice
12 did nothing extra over 10 for me and that still holds a year later
i went to 15 and came back to 10, more suppression wasnt more useful for me
there is no clean conversion between the two, anyone giving you a ratio is guessing
why does everyone talk about 7.5 and not 10
[edited]coming back to this did going from 2.5 semaglutide to 5 of this feel like a step down for anyone
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same plateau here
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
7.5 gang
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how many weeks at 7.5 before you knew it was enough
GIP plus GLP-1
no gap when i switched, took the last semaglutide dose and started this a week later
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
5 was where i first noticed it properly, 2.5 did almost nothing for me
whats the top licensed dose, 15 or does it go higher
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folklore probably
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
SURMOUNT is weight
anyone got a 4 recon they like for the 30 vials
SURMOUNT is weight
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)Reminder for eight_mm: dose day is today. Set 5 days ago.
anyone stopped at 10 and stayed there for months
plateaued at 33 weeks the same way i did on semaglutide, so i doubt its compound specific
[edited]$120 for a 30 vial is roughly what ive paid for the last year
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the sweet spot thing is survivorship, the people it worked for stayed and said so
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ok so back after 6 months, do i restart at 2.5 or pick up near where i left off
10 was enough
at 15 the GI came back for me, so my easier profile claim only applies below that
5 was where i first noticed it properly, 2.5 did almost nothing for me
im at 12 and thinking about 1.7, did anyone gain anything from that step
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the 10 vial in 0.5ml gives 5mg/ml which puts 1 on 5 units, nice round numbers, i could be wrong
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switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it, still working it out
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is 7.5 really the sweet spot or is that just channel folklore
coming off semaglutide, is there a conversion or do i restart at 2.5
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the 2.5 to 5 step was the roughest one for me and everything after was easier
at 5 my appetite is gone entirely, did anyone go down rather than up
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