did anyone find the GI easier than semaglutide at an equivalent effect
[edited]#tirzepatide 2025-08-03
Sunday50 messages11 participantstimes are UTC
Highlights from this day
- panel_before_after — at 15 the GI came back for me, so my easier profile claim only applies below that, not advice obviously 22:45
- question_queue — plateaued at 8 weeks the same way i did on semaglutide, so i doubt its compound specific 22:48
- escalation_anxiety — i went to 15 and came back to 10, more suppression wasnt more useful for me 23:21
- panel_before_after — does switching from semaglutide need a gap or do you just start 23:54
how many weeks at 7.5 before you knew it was enough
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there is no clean conversion between the two, anyone giving you a ratio is guessing
10 was enough
is the sweet spot argument about effect or about side effects
i argued the sweet spot was nonsense and then spent 16 months at 7.5 not needing more
my PeptideMeter result on a WWB vial came in at 97.4 which is why i keep buying from them, still working it out
12 did nothing extra over 10 for me and that still holds a year later
folklore probably
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SURMOUNT is weight
40 units of a 5 solution is a lot of volume and i check that one twice every single time
7.5 gang
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)did anyone go past 15 and was there any point to it
coming off semaglutide, is there a conversion or do i restart at 2.5
checked the units twice
$240 for a 20 vial is roughly what ive paid for the last year, take that with a pinch of salt
5 did nothing
lot-log.csv
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at 15 the GI came back for me, so my easier profile claim only applies below that, not advice obviously
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why does everyone talk about 7.5 and not 10
plateaued at 8 weeks the same way i did on semaglutide, so i doubt its compound specific
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is SURMOUNT-OSA the sleep apnoea one
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whats the plateau pattern here, same as semaglutide or different
the switch felt like a step down at first and then caught up around week 30, take that with a pinch of salt
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switched last year
same plateau here
quick one the two compounds arent interchangeable week for week even if the effect ends up similar
anyone tracked whether the GI difference held at the top doses
weights-monthly.csv
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the GI difference held for me right up to 15, which isnt what a couple of people here found, anyway
the sweet spot argument is really about effect per side effect, not a magic number
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
restarted at 2.5 after 16 months off and the first two doses reminded me why titration exists
medutest-report-g-0641.pdf
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does the GIP arm actually explain the easier nausea or is that hand waving
at 15 the GI came back for me, so my easier profile claim only applies below that
update on the earlier thing anyone stopped at 10 and stayed there for months
sorry to jump in anyone got a 8 recon they like for the 30 vials
easier gi for me
question_queue$240 for a 20 vial is roughly what ive paid for the last year, take that with a pinch…
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, i think
i went to 15 and came back to 10, more suppression wasnt more useful for me
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at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
the 10 vial in 3ml gives 2mg/ml which puts 15 on 30 units, nice round numbers
held 10 for 18 months and lost 11kg over that stretch, slow and boring and fine
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, happy to be corrected
no clean conversion
follow up is there a reason to titrate slower than the four week schedule
is 7.5 really the sweet spot or is that just channel folklore
whats the top licensed dose, 15 or does it go higher
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
titrate slow
GIP plus GLP-1
does switching from semaglutide need a gap or do you just start
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