SURMOUNT is weight
#tirzepatide 2025-08-17
Sunday38 messages9 participantstimes are UTC
Highlights from this day
- swirl_not_shake — held 10 for 17 months and lost 37kg over that stretch, slow and boring and fine 17:09
- swirl_not_shake — while im here did anybody switch back to semaglutide after trying this 17:12
- swirl_not_shake — does the appetite effect feel different or just stronger 17:18
- noct.titrate — genuine question why does everyone talk about 7.5 and not 10 17:54
- split_shipment — coming back to this SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 19:59
5 did nothing
the GI difference held for me right up to 15, which isnt what a couple of people here found
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same plateau here
7.5 gang
no clean conversion
at 15 the GI came back for me, so my easier profile claim only applies below that
anyone got a 5 recon they like for the 10 vials
[edited]GIP plus GLP-1
[edited]switched last year
held 10 for 17 months and lost 37kg over that stretch, slow and boring and fine
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while im here did anybody switch back to semaglutide after trying this
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is the sweet spot argument about effect or about side effects
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no gap when i switched, took the last semaglutide dose and started this a week later
does the appetite effect feel different or just stronger
coming back to this 5 was where i first noticed it properly, 2.5 did almost nothing for me
did anyone find the GI easier than semaglutide at an equivalent effect
the trials titrated every four weeks to a target, most people here stop at whatever works
titrate slow
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easier gi for me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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back after 26 months, do i restart at 2.5 or pick up near where i left off
slightly off topic but the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, from memory
genuine question why does everyone talk about 7.5 and not 10
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10 was enough
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i argued the sweet spot was nonsense and then spent 15 months at 7.5 not needing more
at 5 my appetite is gone entirely, did anyone go down rather than up
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the sweet spot thing is survivorship, the people it worked for stayed and said so
18:37ferrous_ash pinned a message to this channel
the sweet spot argument is really about effect per side effect, not a magic number, i think
went back to semaglutide after 5 months because the cost difference mattered more than the GI, ill dig out the number
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
the 40 vial in 3ml gives 2.5mg/ml which puts 1.7 on 15 units, nice round numbers
there is no clean conversion between the two, anyone giving you a ratio is guessing
unrelated but does the GIP arm actually explain the easier nausea or is that hand waving
coming back to this SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
plateaued at 21 weeks the same way i did on semaglutide, so i doubt its compound specific
[edited]restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, n of 1 obviously
[edited]