no gap when i switched, took the last semaglutide dose and started this a week later
#tirzepatide 2025-08-28
Thursday58 messages13 participantstimes are UTC
Highlights from this day
- triple_ag_tom — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, n of 1 obviously 40 units of a 8 solution is a lot of volume and i… 18:08
- power_cut_pia — i went to 15 and came back to 10, more suppression wasnt more useful for me 20:19
- cross_border_cam — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 21:28
- cross_border_cam — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, i have it written down somewhere 21:45
why does everyone talk about 7.5 and not 10
update on the earlier thing is SURMOUNT-OSA the sleep apnoea one
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, n of 1 obviously
40 units of a 8 solution is a lot of volume and i check that one twice every single time
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
Reminder set. I will post here in 6 days.
genuine question anyone tracked whether the GI difference held at the top doses
same plateau here
[edited]titrate slow
whats the top licensed dose, 15 or does it go higher
Reminder set. I will post here in 4 days.
i sat at 7.5 for 14 months and never needed more, which is where the folklore comes from
at 15 the GI came back for me, so my easier profile claim only applies below that
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the sweet spot argument is really about effect per side effect, not a magic number
is the 2 vial the common one or do people use 30
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
40 units of a 10 solution is a lot of volume and i check that one twice every single time
*week 9 not week 4
12 did nothing extra over 10 for me and that still holds a year later
did anyone find the GI easier than semaglutide at an equivalent effect
7.5 gang
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whats the plateau pattern here, same as semaglutide or different
cross_border_cami sat at 7.5 for 14 months and never needed more, which is where the folklore comes from
the switch felt like a step down at first and then caught up around week 5
genuine question did anybody switch back to semaglutide after trying this
5 was where i first noticed it properly, 2.5 did almost nothing for me
the 2.5 to 5 step was the roughest one for me and everything after was easier
how did people handle the 2.5 to 5 jump
€55 for a 2 vial is roughly what ive paid for the last year
went back to semaglutide after 10 months because the cost difference mattered more than the GI
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anyone stopped at 10 and stayed there for months
does switching from semaglutide need a gap or do you just start
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Recon calculator: 5mg in 2ml = 2mg/ml.
coming back to this the 40 vial in 3ml gives 10mg/ml which puts 1 on 10 units, nice round numbers
10 was enough
anyone got a 8 recon they like for the 10 vials
i went to 15 and came back to 10, more suppression wasnt more useful for me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
folklore probably
at 2 my appetite is gone entirely, did anyone go down rather than up
no clean conversion
did anyone go past 15 and was there any point to it
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
unrelated but is there a reason to titrate slower than the four week schedule
easier gi for me
held 10 for 22 months and lost 36kg over that stretch, slow and boring and fine
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the sweet spot thing is survivorship, the people it worked for stayed and said so
GIP plus GLP-1
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
the two compounds arent interchangeable week for week even if the effect ends up similar
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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the trials titrated every four weeks to a target, most people here stop at whatever works
5 did nothing
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, i have it written down somewhere
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how long before the dual thing was noticeable to you
restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists
there is no clean conversion between the two, anyone giving you a ratio is guessing
start low anyway
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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SURMOUNT is weight