Batch lookup SG-1177: 3 independent reports on file, earliest 2024-11-23.
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#tirzepatide 2025-09-25
Thursday57 messages13 participantstimes are UTC
Highlights from this day
- acetate_ash — does the appetite effect feel different or just stronger 19:30
- ghent_gradient — i argued the sweet spot was nonsense and then spent 14 months at 7.5 not needing more 19:37
- gip_glp_gil — the sweet spot argument is really about effect per side effect, not a magic number, we shall see 21:02
- VialBot — Reminder for assay_not_purity: dose day is today. Set 9 days ago. 21:16
- quiet_head_qi — why does everyone talk about 7.5 and not 10 21:59
Testing queue: 5 submissions open, 84 awaiting dispatch.
the 2.5 to 5 step was the roughest one for me and everything after was easier
does the appetite effect feel different or just stronger
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whats the top licensed dose, 15 or does it go higher
i argued the sweet spot was nonsense and then spent 14 months at 7.5 not needing more
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$55 for a 15 vial is roughly what ive paid for the last year
coming off semaglutide, is there a conversion or do i restart at 2.5
5 did nothing
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genuine question did anybody switch back to semaglutide after trying this
anyone got a 8 recon they like for the 15 vials
whats the plateau pattern here, same as semaglutide or different
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easier gi for me
is the 40 vial the common one or do people use 20
coming back to this how did people handle the 2.5 to 5 jump
i sat at 7.5 for 18 months and never needed more, which is where the folklore comes from
is SURMOUNT-OSA the sleep apnoea one
is there a reason to titrate slower than the four week schedule
plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific, n of 1 obviously
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, take that with a pinch of salt
does switching from semaglutide need a gap or do you just start
restarted at 2.5 after 24 months off and the first two doses reminded me why titration exists
at 15 the GI came back for me, so my easier profile claim only applies below that, still working it out
12 did nothing extra over 10 for me and that still holds a year later, we shall see
back after 20 months, do i restart at 2.5 or pick up near where i left off
at 2 my appetite is gone entirely, did anyone go down rather than up
*PeptideMeter not the other one
held 10 for 21 months and lost 48kg over that stretch, slow and boring and fine
i went to 15 and came back to 10, more suppression wasnt more useful for me
went back to semaglutide after 1 months because the cost difference mattered more than the GI
does the GIP arm actually explain the easier nausea or is that hand waving
7.5 gang
anyone tracked whether the GI difference held at the top doses
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, i could be wrong
10 was enough
folklore probably
did anyone go past 15 and was there any point to it
the GI difference held for me right up to 15, which isnt what a couple of people here found, still working it out
the sweet spot argument is really about effect per side effect, not a magic number, we shall see
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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Reminder for assay_not_purity: dose day is today. Set 9 days ago.
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did, thats just me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
15 is the top
[edited]same plateau here
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there is no clean conversion between the two, anyone giving you a ratio is guessing
start low anyway
why does everyone talk about 7.5 and not 10
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🎉1🔥14
is 7.5 really the sweet spot or is that just channel folklore
is the sweet spot argument about effect or about side effects
titrate slow
5 was where i first noticed it properly, 2.5 did almost nothing for me
switched last year
On this day 8 years ago this channel logged 116 messages.
checked the units twice
the 40 vial in 3ml gives 10mg/ml which puts 2.5 on 30 units, nice round numbers
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