the sweet spot thing is survivorship, the people it worked for stayed and said so
#tirzepatide 2025-10-09
Thursday19 messages5 participantstimes are UTC
Highlights from this day
- subq_sy — at 15 the GI came back for me, so my easier profile claim only applies below that 22:42
- subq_sy — went back to semaglutide after 12 months because the cost difference mattered more than the GI 23:08
- subq_sy — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 23:20
SURMOUNT is weight
GIP plus GLP-1
40 units of a 10 solution is a lot of volume and i check that one twice every single time
the 40 vial in 1ml gives 8mg/ml which puts 12 on 40 units, nice round numbers
restarted at 2.5 after 23 months off and the first two doses reminded me why titration exists
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
checked the units twice
coming back to this the two compounds arent interchangeable week for week even if the effect ends up similar
at 15 the GI came back for me, so my easier profile claim only applies below that
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the trials titrated every four weeks to a target, most people here stop at whatever works
update on the earlier thing i sat at 7.5 for 14 months and never needed more, which is where the folklore comes from
15 is the top
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start low anyway
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does switching from semaglutide need a gap or do you just start
janoshik-b-0114.pdf
2 pages · 912 KB · not retained in the public archive
went back to semaglutide after 12 months because the cost difference mattered more than the GI
janoshik-e-2205.pdf
2 pages · 347 KB · not retained in the public archive
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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why does everyone talk about 7.5 and not 10
the sweet spot argument is really about effect per side effect, not a magic number
sorry to jump in switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it