Digest for the week of 2025-03-29 has been published.
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#tirzepatide 2025-10-31
Friday29 messages6 participantstimes are UTC
Highlights from this day
- VialBot — Digest for the week of 2025-03-29 has been published. 16:58
- snac_and_water — ok so my PeptideMeter result on a SGN vial came in at 98.1 which is why i keep buying from them, take that with a pinch of salt 17:01
- lot_number_lou — if youre coming off semaglutide the honest answer is start low and find out, theres no table 17:41
- thirty_min_wait — i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from, thats one data point 18:56
- never_for_sale — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 20:22
ok so my PeptideMeter result on a SGN vial came in at 98.1 which is why i keep buying from them, take that with a pinch of salt
the two compounds arent interchangeable week for week even if the effect ends up similar
changed my mind about needing 15, i was chasing a number rather than an outcome
held 10 for 15 months and lost 19kg over that stretch, slow and boring and fine
slightly off topic but dual agonist, GIP as well as GLP-1, thats the whole difference in one line
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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plateaued at 16 weeks the same way i did on semaglutide, so i doubt its compound specific, your mileage will differ
how did people handle the 2.5 to 5 jump
10 was enough
titrate slow
snac_and_waterok so my PeptideMeter result on a SGN vial came in at 98.1 which is why i keep buying…
did anybody switch back to semaglutide after trying this
follow up switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it, not advice obviously
GIP plus GLP-1
[edited]did anyone find the GI easier than semaglutide at an equivalent effect
the GI difference held for me right up to 15, which isnt what a couple of people here found
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
never_for_salefollow up switched from 12 semaglutide and started at 2.5, took the slow route, never…
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the two compounds arent interchangeable week for week even if the effect ends up similar
restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists, n of 1 obviously
is there a reason to titrate slower than the four week schedule
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did going from 0.25 semaglutide to 5 of this feel like a step down for anyone
follow up whats the top licensed dose, 15 or does it go higher
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from, thats one data point
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
went back to semaglutide after 3 months because the cost difference mattered more than the GI
quick one SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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15 is the top
while im here at 15 the GI came back for me, so my easier profile claim only applies below that
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